Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
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Study on Antitumor Effect of Kamicheungyeolhaedogtang(KCHT)(I)

가미청열해독탕(加味淸熱解毒湯)의 항암활성(抗癌活性)에 관(關)한 연구(硏究)( I )

  • Kim, Gyu (Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Taejon University) ;
  • Kim, Dong-Hee (Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Taejon University) ;
  • Choi, Bong-Gyoon (Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Taejon University) ;
  • Kim, Sung-Hoon (Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Taejon University)
  • 김규 (대전대학교 한의과대학 병리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 최봉균 (대전대학교 한의과대학 병리학교실) ;
  • 김성훈 (대전대학교 한의과대학 병리학교실)
  • Published : 2000.02.25
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Abstract

To evaluate the antitumor activity and antimetastatic effects of Kamicheungyeolhaedog tang(KCHT), studies were done experimentally. The results were obtained as follows: 1. KCHT extracts exhibited a significant cytotoxicity against A549, SK-MEL-2, SK-OV-3, and B16-BL6 cell lines. 2. KCHT extracts showed significant inhibitoty effect on DNA topoisomerase I 3. The T/C% was 145.8% in KCHT treated group in S-180 bearing ICR mice. 4. KCHT extracts exhibited efficient affect adhesive effect of A549, B16-BL6 cell to complex extracellular matrix. 5. In vitro neovascularization assays, angiogenesis was insignificantly inhibited in KCHT treated group as compared with control group. These results suggested that KCHT extracts might be usefully applied for prevention and treatement of cancer.

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