Journal of Periodontal and Implant Science
- 제30권2호
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- Pages.359-374
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- 2000
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
저염식으로 유도한 Cyclosporine 신독성 백서에서의 치은 변화
Comparative Study of Gingival Changes in Cyclosporine-Induced Nephrotoxicity with Normal and Low Salt Diet
- Lim, Jae-Gye (Department of Oral Pathology, College of Dentistry, Kyungpook University) ;
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Kim, Yong-Jin
(Dept. of Pathology, Yeungnam University College of Medicine) ;
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Park, Yong-Hoon
(Dept. of Pediatrics, Yeungnam University College of Medicine)
- 발행 : 2000.06.30
초록
Cyclosporine A(CsA) is a widely used immunosuppressant for transplant patients and is also used for the treatment of a wide variety of systemic diseases with immunologic disorders. However, its use is frequently limited because of complications such as nephrotoxicity or gingival hyperplasia. Although several hypotheses have been postulated for CsA-induced gingival hyperplasia, i.e. various cytokine effects of inflammatory cells, existence of plaque or CsA itself, but its pathogenesis is still unclear. For experimental chronic CsA toxicity, salt depletion has been shown to increased susceptibility of rodents to the effects of CsA, and this maneuver facilitates production of arteriolopathy and interstitial fibrosis in kidney that mimic the changes found in human. The purpose of this study was to evaluate pathogenesis of CsA-induced gingival hyperplasia by comparing changes between CsA administration groups of normal standard diet and those of low salt diet group. Specific pathogen-free, 20 to 25 days old(120 to 150 g), male Fisher-344 rats(KIST, Korea), 120 to 150g of body weight, were assigned to four groups of six animals each after one week of adaptation period for powder food. Group 1 received olive oil(