The Evaluation of Artificial Lung Using Blood Substitutes

대체혈액을 이용한 인공폐의 평가에 관한 연구

  • Kim K.B. (School of Chemical Eng., College of Engineering, Chonbuk National University) ;
  • Hong S C. (Dept. of Microbiology, Medical School, Chonbuk National University) ;
  • Kim M.H. (Dept. of Thoracic and Cardiovascular Surgery, Medical School, Chonbuk National University) ;
  • Jheong G.R. (School of Chemical Eng., College of Engineering, Chonbuk National University) ;
  • Lee S.C. (Dept. of Advanced Materials Engineering, Hanlyo University)
  • 김기범 (한려대학교 신소재공학과) ;
  • 홍성출 (전북대학교 의과대학 미생물학교실) ;
  • 김민호 (전북대학교 의과대학 흉부외과학교실) ;
  • 정경락 (한려대학교 신소재공학과) ;
  • 이삼철 (전북대학교 공과대학 화학공학부)
  • Published : 2000.06.01

Abstract

In this paper a newly designed oxygenator module was used to perform the experiments for pressure drop and oxygen transport in order to evaluate the efficiency of the artificial lung. Also, distilled water. sodium sulfite solutions used in this experiment were evaluated for the performance of other artificial lungs. Substituted bloods have many advantages over whole blood in studying pressure drop and oxygen uptake. They are relatively inexpensive, and require fewer variables to be controlled. Furthermore, deoxygenation is not necessary when those solutions are used. In addition to these advantages. assays and interpretation of the experimental results are relatively easy. In the case of using the sodium sulfite solution having the same oxygen partial pressure as whole blood. the oxygen transfer rate of the sodium sulfite solution was basically same as that of whole blood. It was concluded in evaluating the function of artificial lungs that the sodium sulfite solution was suited for measuring oxygen transfer rate. In our module, artificial blood was flowed into the outside of hollow fiber membrane. The artificial lung created in this experiment showed that pressure drop was reduced to $1/3\~1/6$ of that compared to the inside-flow case.

본 연구에서는 새롭게 설계한 인공폐 모듈을 사용하여 인공폐의 효율을 평가하기 위한 압력손실과 산소전달에 대한 실험을 수행하였다. 또한 증류수, 아황산나트륨용액을 혈액대용물질로 사용하여 다른 인공폐의 성능을 평가하였다. 혈액대용물질은 압력손실과 산소운반력을 연구하는데 전혈(whole blood)에 비해 장점이 많다 즉. 이들은 상대적으로 값이 저렴하고 조절하여야 할 변수가 적다. 또한 이 용액을 사용하게 되면 탈산화장치가 필요 없으며 실험결과의 분석이 상대적으로 쉽다. 전혈과 같은 산소분압을 갖는 아황산나트륨용액을 사용하는 경우 아황산나트륨 용액의 산소전달속도는 전혈을 사용하는 경우의 산소전달속도와 거의 일치하였다. 이 실험에서 중공사모듈의 산소전달속도를 측정하는데 아황산나트륨용액이 혈액대용물질로 이용될 수 있음을 보였다. 이 인공폐 모듈에서는 용액이 중공사의 바깥쪽으로 흐르도록 설계하였는데 이 실험용 인공폐는 압력손실이 안쪽으로 흐르도록 하는 흐름에 비해 $1/3\~1/6$였다.

Keywords

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