The Journal of the Korean Society for Microbiology (대한미생물학회지)

The Korea Society for Microbiology (대한미생물학회)
권호 표지

Involvement of the CXC Chemokines Mig and IP-10 in Response to M. bovis BCG in Mice

  • Hong, Seong-Tshool (Department of Microbiology, Chonbuk National University Medical School) ;
  • Cho, Jung-Gil (Department of Microbiology, Chonbuk National University Medical School) ;
  • Lee, Hwang-Ho (Department of Microbiology, Chonbuk National University Medical School)
  • Published : 2000.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

The non-ELR-containing CXC chemokines Mig and IP-10 have been shown to function as chemotactic cytokines for activated T lymphocytes. In this study, we examined the potential involvement of Mig and IP-10 in antimycobacterial response of mice immunized or infected with M. bovis BCG. The accumulation of Mig and IP-10 mRNA in resident peritoneal monocytes ($RPM{\Phi}$) was slightly reduced by stimulation with vBCG, and the degree was greater for 24 hr culture even though IFN-${\gamma}$ was added. Expression of Mig, IP-10, and IFN-${\gamma}$ in 24 hr delayed-type hypersensitivity (DTH) response was stronger in vBCG-immune mice than in the non-immune. The increase of DTH measured by foot-pad thickness appears to be clearly related to the levels of chemokines Mig and IP10 messages and those of IFN-${\gamma}$ and IL-12. Stimulation with vBCG for 2 days decreased or completely dropped the levels of Mig message in non-immune or immune splenocytes, respectively, whereas IP-10 message was slightly decreased in 2 days culture. Moreover, messages for IL-12 (p40) showed similar kinetics for Mig. The levels of Mig and IP-10 mRNA during the course of infection with BCG were not readily changed in lungs, livers, and spleens from BCG-infected mice. Although there was no obvious changes of Mig and IP-10 messages in the target organs during infection process, we found that the infection progressed over the first 3 wk before being contained by the emerging immune response suggested from detectable amount of IFN-${\gamma}$ mRNA around this time. In view of selectivity of chemokines Mig and IP-10 for activated T cells, these data suggest that chemokine Mig and IP-10, especially in collaboration with IL-12 and IFN-${\gamma}$, may playa role as T cell recruiters in immune response against mycobacterial infection.

Keywords

References

  1. J Exp Med v.182 Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo Angiolillo, A.L.;Sgadari, C.;Taub, D.D.;Liao, F.;Farber, J.M.;Maheshwari, S.;Kleinman, H.K.;Reaman, G.H.;Tosato, G.
  2. Science v.269 no.5231 Activation of dual T cell signaling pathways by the chemokine RANTES Bacon, K.B.;Premack, B.A.;Gardner, P.;Schall, T.J.
  3. J Exp Med v.184 A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) Bleul, C.C.;Fuhlbrigge, R.C.;Casasnovas, J.M.;Aiuti, A.;Springer, T.A.
  4. Science v.270 Identification of RANTES, $MIP-1{\alpha}, \; and \;MIP-1{\beta}$ as the major HIV-suppressive factors produced by $CD8^+$ T cells Cocchi, F.;Devico, A.L.;Gargino-Demo, A.;Arya, S.K.;Gallo, R.C.;Russo, P.
  5. J Exp Med v.187 no.12 Interferon inducible T-cell ${\alpha}$ chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T-cells through selective high affinity binding to CXCR3 Cole, K.E.;Strick, C.A.;Paradis, T.J.;Ogborne, K.T.;Loetscher, M.;Glaude, R.P.;Lin, W.;Boyd, J.G.;Moser, B.;Wood, D.E.;Sahagan, B.G.;Neote, K.J.
  6. Am Rev Respir Dis v.113 Distribution of in vivo grown mycobacteria in the organs of intravenously infected mice Collins, F.M.;Montalbine, V.
  7. Science v.259 Multiple defects of immune cell function in mice with disrupted $interferon-{\gamma}$ genes Dalton, D.K.;Pitts-Meek, S.;Keshav, S.;Figari, I.S.;Bradley, A.;Stewart, T.A.
  8. J Exp Med v.179 Production of the RANTES chemokine in delayed-type hypersensitivity reactions: involvement of macrophages and endothelial cells Devergne, O.;Marfaing-Koka, A.;Schall, T.T.;Leger-Ravet, M.B.;Sadick, M.;Peuchmaur, M.;Crevon, M.C.;Kim, T.;Galanaud, P.
  9. Biochem Biophys Res Commun v.192 HuMIG: a new human member of the chemokine family of cytokines Farber, J.M.
  10. Proc Natl Acad Sci (USA) v.87 A macrophase mRNA selectively induced by ${\gamma}-interferon$ encodes a member of the platelet factor 4 family of cytokines Farber, J.M.
  11. Mol Cell Biol v.12 A Collection of mRNA species that are inducible in the RAW 264.7 mouse macrophage cell line by gamma interferon and other agents Farber, J.M.
  12. J Exp Med v.181 Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon ${\gamma}$ and tumor necrosis factor ${\alpha}$ Flesch, I.E.A.;Hess, J.H.;Huang, S.;Aguet, M.;Rothe, J.;Bluethmann, H.;Kaufmann, S.H.E.
  13. Euro J Immunol v.22 Secretion of IL-8 following phagocytosis od Mycobacterium tuberculosis by human monocyte cell lines Friedland, J.S.;Remick, D.G.;Shattock, R.;Griffin, G.E.
  14. Cytokine v.5 Phagocytosis of Mycobacterium tuberculosis or particulate stimuli by human monocytic cells induces equivalent monocyte chemotactic protein-1 gene expression Friedland, J.S.;Shattock, R.J.;Griffin, G.E.
  15. Infect Immun v.64 Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis Fulton, S.A.;Johnsen, J.M.;Wolf, S.F.;Sieburth, D.S.;Boom, W.H.
  16. J Leukoc Biol v.64 Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12 Kanegane, C.;Sgadari, C.;Kanegane, H.;Teruya-Feldstein, J.;Yao, L.;Gupta, G.;Farber, J.M.;Liao, F.;Liu, L.;Tosato, G.
  17. J Exp Med v.166 The expression of a interferon-inducible protein (IP-10) in delayed immune responses in human skin Kaplan, G.;Luste, A.D.;Hancock, G.;Cohn, Z.A.
  18. J Infect Dis v.130 Relationship of delayed-type hypersensitivity and acquired cellular resistance in experimental airborne tuberculosis Knight-Shapiro, C.D.;Harding, G.E.;Smith, D.W.
  19. Am J Respir Crt Care Med v.155 Elevated chemokine levels in bronchoalveolar lavage fluid in tuberculosis patients Kurashima, K.;Mukaida, N.;Fujimura, M.;Yasui, M.;Nakazumi, Y.;Matsuda, T.;Matsushima, K.
  20. Cytogenet Cell Genet v.74 Localization of the gene for the human MIG cytokine on chromosome 4q21.21 adjacent to INP10 reveals a chemokine Lee, H.H.;Farber, J.M.
  21. Kor J Immunol v.21 no.4 $IFN-{\gamma}$ enhances induction of chemokines Mig and IP-10 mRNA from THP-1 cells stimulated with lipoarabinomannan Lee, H.H.
  22. J Exp Med v.182 Human Mig chemokine: biochemical and functional characterization Liao, F.;Rabin, R.L.;Yannelli, J.R.;Koniaris, L.G.;Vanguri, P.;Farber, J.M.
  23. J Exp Med v.184 Chemokine receptor specific for IP-10 and Mig: structure, function and expression in activated T lymphocytes Loetcher, M.;Gerber, B.;Loetcher, P.;Jones, S.A.;Piali, L.;Clark-Lewis, I.;Baggiolini, M.;Moser, B.
  24. Nature v.315 ${\gamma}-Interferon$ transcriptionally regulates an early-response gene containing homology to platelet proteins Luster, A.D.;Unkeless, J.C.;Ravetch, J.V.
  25. Crit Rev Immunol v.12 no.1-2 Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines Miller, M.D.;Krangel, M.S.
  26. Annu Rev Immunol v.12 The molecular biology of leukocyte chemoattractant receptors Murphy, P.
  27. J Infect Dis v.167 T cell response to Mycobacterium tuberculosis Orme, I.M.;Anderson, P.;Boom, W.H.
  28. N Engl J Med v.338 Global surveillance for antituberculosis-drug resistance Pablos-Mendez, A.;Raviglione, M.C.;Laszlo, A.;Binkin, N.;Rieder, H.L.;Bustreo, F.;Cohn, D.L.;Lambregts-van Weezenbeek, C.S.;Kim, S.J.;Chaulet, P.;Nunn, P.
  29. J Immunol v.129 no.5 Immunopathology of BCG infection in genetically resistant and susceptible mouse strains Pelletier, M.;Forget, A.;Bourassa, D.;Gros, P.;Skamene, E.
  30. Infect Immun v.63 no.10 chemokine response in mice infected with Mycobacterium tuberculosis Rhoades, E.R.;Cooper, A.M.;Orme, I.M.
  31. J Biol Chem v.270 no.45 The functional role of the ELR motif in CXC chemokine-mediated angiogenesis Strieter, R.M.;Polverini, P.J.;Kunkel, S.L.;Arenberg, D.A.;Burdick, M.D.;Kasper, J.;Dzuiba, J.;Van Damme, J.;Walz, A.;Marriott, D.;Sham-Yuen, C.;Roczniak, S.;Shanafelt, A.B.
  32. J Immunol v.161 The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor Tannenbaum, C.S.;Tubbs, R.;Amstrong, D.;Finke, J.H.;Bukowski, R.M.;Hamilton, T.A.
  33. J Exp Med v.177 Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells Taub, D.D.;Lioyd, A.R.;Conlon, K.;Wang, J.M.;Ortaldo, J.R.;Harada, A.;Matsushima, K.;Kelvin, D.J.;Oppenheim, J.J.
  34. J Biol Chem v.265 Identification of CRG-2: an interferon-inducible mRNA predicted to encode a murine monokine Vanguri, P.;Farber, J.M.
  35. J Clin Invest v.93 Interleukin 12 at the site of disease in tuberculosis Zhang, M.;Gately, M.K.;Wang, E.;Gong, J.;Wolf, S.F.;Lu, S.;Modlin, R.L.;Barnes, P.F.