The Journal of Korean Society of Virology (대한바이러스학회지)

The Korean Society of Virology (대한바이러스학회)
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Isolation of Apodemus peninsulae-borne Hantavirus and Comparison of Molecular Biological Characteristics

흰넓적다리붉은쥐 유래 한타바이러스 분리 및 분자생물학적 특성 비교

  • Song, Ki-Joon (Department of Microbiology, College of Medicine, The Institute of Viral Diseases, Korea University) ;
  • Yun, Hyung-Seon (Graduate School, Korea University) ;
  • Kho, Eun-Young (Department of Microbiology, College of Medicine, The Institute of Viral Diseases, Korea University) ;
  • Chung, Ki-Mo (Department of Microbiology, College of Medicine, The Institute of Viral Diseases, Korea University) ;
  • Park, Kwang-Sook (Department of Microbiology, College of Medicine, The Institute of Viral Diseases, Korea University) ;
  • Lee, Yong-Ju (Department of Microbiology, College of Medicine, The Institute of Viral Diseases, Korea University) ;
  • Song, Jin-Won (Department of Microbiology, College of Medicine, The Institute of Viral Diseases, Korea University) ;
  • Baek, Luck-Ju (Department of Microbiology, College of Medicine, The Institute of Viral Diseases, Korea University)
  • 송기준 (고려대학교 의과대학 미생물학교실, 고려대학교 바이러스병연구소) ;
  • 윤형선 (고려대학교 대학원) ;
  • 고은영 (고려대학교 의과대학 미생물학교실, 고려대학교 바이러스병연구소) ;
  • 정기모 (고려대학교 의과대학 미생물학교실, 고려대학교 바이러스병연구소) ;
  • 박광숙 (고려대학교 의과대학 미생물학교실, 고려대학교 바이러스병연구소) ;
  • 이용주 (고려대학교 의과대학 미생물학교실, 고려대학교 바이러스병연구소) ;
  • 송진원 (고려대학교 의과대학 미생물학교실, 고려대학교 바이러스병연구소) ;
  • 백락주 (고려대학교 의과대학 미생물학교실, 고려대학교 바이러스병연구소)
  • Published : 2000.03.30
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Abstract

Two distinct hantaviruses have been isolated from Apodemus agrarius in 1976 and Rattus norvegicus in 1980 in Korea. Since our serosurveys conducted in 1994, a genetically distinct hantavirus from Apodemus peninsulae has been investigated. To isolate hantavirus from Apen insulae captured in Korea, the lung homogenate of seropositive Apeninsulae inoculated Vero E6 cells. Viral antigen was detected in a progressively higher percentage of cells with subsequent passage after 80 days postinoculation. The new isolate from seropositive Apodemus peninsulae was designated Suchong virus after Suchong valley located in northeastern region of South Korea. Comparing with hantaan virus 76-118 strain, Suchong virus-1, 2, 3 and 4 showed the similarity of $71.0{\sim}91.8%$ at nucleotide and $90.9{\sim}94.8%$ at amino acid sequences in 231 nucleotides region of M segment, and the similarity of $75.1{\sim}81.0%$ at nucleotide and $97.5{\sim}100%$ at amino acid sequences in 237 nucleotides of S segment.

Keywords