Isolation, Structure Determination and Biological Activity of 25-Epi, $3{\alpha}-Carboxyacetylquercinic$ Acid in Daedalea dickinsii

띠미로버섯 중 25-Epi, $3{\alpha}-Carboxyacetylquercinic$ Acid의 분리정제, 구조결정 및 생리활성

In order to develope bioactive substances, dried fmit body of Daedalea dickinsii collected from Taeback mountain was extracted with ethanol, The compounds 1 and 2 were purified by solvent extraction, silica gel column chromatography and recrystallization from the ethanol extracts. Melting point, molecular weight and molar extinction coefficient of the compound 1 were estimated to be $167{\sim}168^{\circ}C$, 572 and 5,040 at 208 nm. The structure of this compound 1 has been elucidated to be 24S, 25S, $3{\alpha}-carboxyacetylquercinic$ acid using spectroscopic properties. This compound showed antibiotic activities against fungi, yeasts and bacteria and it also showed anticancer activity $IC_{50}=64.5\;{\mu}M$) against Korean stomach cancer cell. Melting point, molecular weight and molar extinction coefficient of the compound 2 were estimated to be $233{\sim}235^<\circ}$, 572 and 5,080 at 208 nm. The structure of this compound was elucidated to be 24S, 25R, $3{\alpha}-carboxyacetylquercinic$ acid. The compound 2 showed different antibiotic activities with the compound 1.

띠미로버섯의 에탄올 추출물 중 25-Epi, $3{\alpha}-carboxyacetylquercinic$ acid의 두 구조, 항균활성 및 항암활성을 연구하였다. 화합물 1의 녹는점과 분자량은 각각 $167{\sim}168^{\circ}C$, 572였고, 몰 흡광 계수는 208 nm에서 5,040이었다. 여러 분광학적 성질로부터 이는 24S, 25S, $3{\alpha}-carboxyacetylquercinic$ acid로 확인되었고, 곰팡이, 효모 및 세균들에 대한 항균활성과 항암활성($IC_{50}=64.5\;{\mu}M$)이 있었다. 화합물 2의 녹는점, 분자량 및 몰흡광 계수는 각각 $233{\sim}235^<\circ}$, 572 및 208 nm에서 5,080이었다. 이는 24S, 25R, $3{\alpha}-carboxyacetylquercinic$ acid로 확인되었고, 화합물 1과 서로 다른 항균활성을 보였다.