대한화학회지 (Journal of the Korean Chemical Society)
- 제44권1호
- /
- Pages.30-36
- /
- 2000
- /
- 1017-2548(pISSN)
- /
- 2234-8530(eISSN)
팔라듐 촉매를 이용한 (2R)-2-(N,N-Ditosylimido)-3-butenyl methyl malonate의 거대고리화 반응
A Macrocyclization of (2R)-2-(N,N-Ditosylimido) -3-butenyl methyl malonate by Using Palladium Catalyst
- Kim, Gyu-Soon (Department of Chemistry, Hanyang University) ;
- Rhee, Hak-June (Department of Chemistry, Hanyang University)
- 발행 : 2000.02.20
초록
A-factor,(3R)-2-(6-methylheptanoyl)-3-hydroxymethyl-4-butanolide(1)의 전합성을 위하여 선택된 중간체, (2R)-2-(N,N-ditosylimido)-3-butenyl methyl malonate(4)의 Pd(0) 촉매 커플링 반응에서 예상과는 다르게 14각 고리화합물인 bis(2-methoxycarbonyl-(4E)-hexenolide)(15)가 생성되었다. 이 화합물은 X-ray 결정학을 이용하여 구조를 확인하였다. 이 결과는 다양한 크기의 대칭적인 거대고리화합물을 합성할 수 있다는 것을 제시해 주고 있다.
Upon Pd(0)-catalyzed coupling reaction of (2R)-2-(N,N-ditosylimido)-3-butenyl methyl malonate (4) which was selected for the total synthesis of A-factor, (3R)-2-(6-methylheptanoyl)-3-hydroxy methyl-4-buttinolide (1), an unexpected 14-membered cyclic compound, bis(2-methoxycabonyl-(4E)-hexenolide) (15) was obtained. The structure of this compound was conformed by X-ray crystallography. This result implies that this method can be applied the synthesis of various size of symmetrical macrocyclic compounds.
키워드