Bulletin of the Korean Chemical Society

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Total Synthesis of a New 7-Deoxyidarubicinone Derivative through the Functionalization of an A-Ring Side Chain

  • Published : 20000800
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Abstract

A convenient total synthesis of a new 7-deoxyidarubicinone ivative21,the aglycon of the anticancer anti-biotic idarubicin analogue,is described.Keyfeatures of the synthesis are the Friedel-Crafts acylation and the functionalization of an A-ring si de chain. A synthon 14 for the A and B rings was prepared from intermediate 6 in five steps.

Keywords

References

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