Bulletin of the Korean Chemical Society

  • 제21권7호
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  • Pages.709-711
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  • 2000
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Voltammetric Studies of Guanine and Its Derivatives by (TEX)$Ru(bpy)^{2+/3+}$(/TEX) Mediator on Indium Tin Oxide Electrode

  • 발행 : 20000700
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초록

Oxidizing metal complex mediates the electrochemical oxidation of guanine nucleotides. This catalysis results in an enhancement in cyclic voltammograms that yield the rate constant for the oxidation of guanine by the metal complex via digital simulation. The rate constant of oxidation of guanine by Ru(bpy)3(3+) is 6.4 x 10(5)M(-1)s(-l). The rate constant and the enhanced current depend on the number of phosphate groups on the sugar of nucleotidc. Also the modified guanine bases show different oxidation rate constants following the trend guanine-5'- monophosphatc (GMP) > 8-bromo-guanine-5'-monophosphate (8-Br-GMP) > xanthosine -5'-monophosphate (XMP) > inosinc-5'-monophosphate (IMP). The guanine bases derivatized differently are all distinguishable from one another, providing a basis for studying electrochemistry of DNA and RNA and developing electrochemical biosensors.

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피인용 문헌

  1. Interactions of polypyridyl cobalt complexes with DNA studied by rotating electrode methods vol.35, pp.3, 2005, https://doi.org/10.1007/s10800-004-6309-2
  2. DNA-promoted electrochemical assembly of [Ru(bpy)2IP]3+/2+ at an ITO electrode vol.51, pp.10, 2006, https://doi.org/10.1016/j.electacta.2005.06.031
  3. Electrochemistry of a novel monoruthenated porphyrin and its interaction with DNA vol.600, pp.2, 2000, https://doi.org/10.1016/j.jelechem.2006.10.016
  4. DNA-enhanced assembly of [Ru(bpy)2ITATP]3+/2+ on an ITO electrode vol.52, pp.15, 2000, https://doi.org/10.1016/j.electacta.2007.01.074
  5. Disproportionation of pentaammineruthenium(III)-nucleoside complexes leads to two-electron oxidation of nucleosides without involving oxygen molecules vol.17, pp.8, 2012, https://doi.org/10.1007/s00775-012-0942-8