Bulletin of the Korean Chemical Society

  • 제21권4호
  • /
  • Pages.383-388
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  • 2000
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Polymeric Micelle Formation of Multiblock Copolymer Composed of Poly( $\gamma$-benzyl L-glutamate) and Poly(ethylene oxide)

  • 발행 : 20000400
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초록

Multiblock copolymers consisting of poly( g-benzyl L-glutamate) (PBLG) as the hydrophobic part and poly(ethylene oxide) (PEO) as the hydrophilic part (GEG) were synthesized and characterized. GEG polymeric micelles were prepared by the dialysis technique. Particle size distributions based on intensity,volume, and number-average were 22.6 $\pm$ 11.9 nm, 23.5 $\pm$ 4.6 nm, and 23.7 $\pm$ 37 nm, respectively. It was observed that par-ticle size and size distribution of GEG polymeric micelles changed significantly with the choice of initial sol-vent. Transmission electron micrographs (TEM) showed the polymeric micelles to be spherically shaped, with sizes ranging from 20 nm to 40 nm in diameter. Fluorescence spectroscopy measurements suggested that GEG block copolymers wereassociated in water to form polymeric micelles, and the critical micelle concentrations (CMC) value of the block copolymers was 0.0094 g/L. Further evidenceof micelle formation of GEG block copolymers and limited mobility of the PBLG chain in the core ohe micelle was obtained with 1 H NMR in D2O.

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피인용 문헌

  1. Soft Hydrogels from Nanotubes of Poly(ethylene oxide)−Tetraphenylalanine Conjugates Prepared by Click Chemistry vol.25, pp.4, 2000, https://doi.org/10.1021/la8035659
  2. Self-assembled Polyion Complex Micelles based on PVP-b-PAMPS and PVP-b-PDMAEMA for Drug Delivery vol.25, pp.3, 2000, https://doi.org/10.1177/0883911510362459
  3. Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles vol.37, pp.7, 2020, https://doi.org/10.1080/02652048.2020.1792566