Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Binding Mode of [Ruthenium(II)$(1,10-Phenanthroline)_2L]^{2+}\;to\;Poly(dG){\cdot}poly( dC){\cdot}poly(dC)^+$ Triplex DNA

  • Published : 20001000
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Abstract

Binding geometries of $[Ru(II)(110-phenanthroline)_2L]^2+$, complexes (where L = dipyrido [3,2-a:2',3'-c]phena-zine (DPPZ) or benzodipyrido[3,2-a:2',3'-c] phenazine (BDPPZ)) to poly(dG)${\cdot}$poly(dC)${\cdot}$poly(dC) + triplex DNA (CGC + triplex) has been investigated by linear dichroism and normal absorption spectroscopy. Analysis of the linear dichroism for the CGC+ triplex and $[Ru(II)(phen)_2BDPPZ]^2+$ complex indicates that the extended ligand of the metal complex lie perpendicular to the polynucleotide helix axis. Together with strong hypochromism and red shift in the interligand absorption region, we concluded that the extended BDPPZ or DPPZ ligand in-tercalated between the bases of polynucleotide. The spectral properties of the metal complexes bound to CGC+ triplex are similar to those bound to $poly(dA)[poly(dT)]^2$ triplex (Choi et al., Biochemistry 1997, 36, 214), sug-gesting that the metal complex is located in the minor groove of the CGC+ triplex.

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References

  1. Metal Ions in Biological Systems $Nord\'{e}n$, B.;Lincoln, P.;Akerman, B.;Tuite, E.
  2. J. Chem. Soc., Chem. Commun. Naing, K.;Takahashi, M.;Taniguchi, M.;Yamagishi, A.
  3. J. Photochem. Photobiol. B: Biol. v.23 Feeney, M.;Kelly, J. M.;Tossi, A. B.;Kirsch-De Mesmaeker, A.;Lecomte, J.-P.
  4. J. Photochem. Photobiol. B.: Biol. v.26 Sentagne, C.;Chambron, J. C.;Sauvage, J. P.;Paillous, N.
  5. J. Am. Chem. Soc. v.117 Xu, X. H.;Bard, A. J.
  6. Science v.233 Barton, J. K.
  7. J. Am. Chem. Soc. v.118 Arkin, M. R.;Stemp, E. D. A.;Turro, C.;Turro, N. J.;Barton, J. K.
  8. J. Am. Chem. Soc. v.115 Hiort, C.;Lincoln, P.;$Nord\'{e}$, B.
  9. Biochemistry v.29 Rehmann, J. P.;Barton, J. K.
  10. J. Biocol. Str. Dyn. v.9 Haworth, I. S.;Elcock, A. H.;Freeman, J.;Rodger, A.;Richards, W. G.
  11. J. Am. Chem. Soc. v.114 Eriksson, M.;Leijon, M.;Hiort, C.;$Nord\'{e}n$, B.;Graslund, A.
  12. Biochemistry v.33 Eriksson, M.;Leijon, M.;Hiort, C.;$Nord\'{e}n$, B.;Graslund, A.
  13. Biochemistry v.31 Satyanarayana, S.;Dabrowiak, J. C.;Chaires, J. B.
  14. Biochemistry v.32 Satyanarayana, S.;Dabrowiak, J. C.;Chaires, J. B.
  15. J. Am. Chem. Soc. v.114 Jenkins, Y.;Barton, J. K.
  16. Biochemistry v.31 Jenkins, Y.;Freidman, A. E.;Turro, N. J.;Barton, J. K.
  17. J. Am. Chem. Soc. v.116 Dupureur, C. M.;Barton, J. K.
  18. J. Am. Chem. Soc. v.117 Haq, I.;Lincoln, P.;Suh, D.;$Nord\'{e}n$, B.;Chowdhry, B. Z.;Chaires, J. B.
  19. J. Am. Chem. Soc. v.118 Lincoln, P.;Broo, A.;$Nor\'{e}n$, B.
  20. Biochemistry v.36 Choi, S. D.;Kim, M. S.;Kim, S. K.;Lincoln, P.;Tuite, E.;$Nord\'{e}n$, B.
  21. Nucleic Acid Res. v.15 LeDoan, T.;Perrouault, L.;Praseuth, D.;Habhoub, N.;Decout, J. L.;Thuong, N. T.;Lhomme, J.;$H\'{e}l\`{e}ne$, C.
  22. Science v.238 Moser, H. E.;Dervan, P. B.
  23. Science v.243 Htun, H.;Dahlberg, J. E.
  24. Proc. Natl. Acad. Sci. U.S.A. v.89 Dual-Valentine, G.;Thuong, N. T.;$H\'{e}l\`{e}ne$, C.
  25. Proc. Natl. Acad. Sci. U.S.A. v.90 Giovannangeli, C.;Thuong, N. T.;$H\'{e}l\`{e}ne$, C.
  26. Nucleic Acid Res. v.18 Hanvey, J. C.;Shimizu, M.;Wells, R. D.
  27. Science v.241 Johnston, B. H.
  28. J. biol. Chem. v.266 Scaria, P. V.;Shafer, R. H.
  29. Biochemistry v.35 Marchand, C.;Bailly, C.;Nguyen, C. H.;Visagni, E.;Garestier, T.;$H\'{e}l\`{e}ne$, C.
  30. Biochemistry v.35 Kim, H. K.;Kim, J. M.;Kim, S. K.;Rodger, A.;$Nord\'{e}n$, B.
  31. Bull. Korean Chem. Soc. v.18 Hyun, K. M.;Lee, G. J.;Cho, T. S.;Kim, S, K.;Yi, S. Y.
  32. FEBS Lett. v.315 Kim, S. K.;$Nord\'{e}n$, B.
  33. J. Chem. Soc., Chem. Commun. Tuite, E.;$Nord\'{e}n$, B.
  34. J. Chem. Soc., Chem. Commun. v.31 Lyng, .R.;Rodger, A.;$Mord\'{e}m$
  35. J. Chem. Soc., Chem. Commun. v.32 Lyng, .R.;Rodger, A.;$Mord\'{e}m$
  36. Rev. Biophy. v.25 $Nod\'{e}n, B.'Libosta ,
  37. Appl. Spectrp v.39 $Nord\'{e}n$, B.;Seth, S.
  38. J. Mol. Recogni. v.7 $Nord\'{e}n$, B.;Kurucsev, T.
  39. J. Am. Chem. Soc. v.112 Freidman, A. E.;Chambron, J.-C.;Sauvage, J.-P.;Turro, N. J.;Barton, J. K.

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