Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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The Effect of Sodium Arsenite ($NaAsO_2$) on the Proliferation and Differentiation of Bone Marrow Cell Stimulated by G-CSF to Neutrophilic Granulocyte Lineage Cells

Sodium Arsenite ($NaAsO_2$)가 G-CSF에 의해 neutrophilic granulocyte계열 세포로 성장, 분화가 촉진된 골수 세포에 미치는 영향

  • 한성수 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 박재현 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 정혜주 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 김영옥 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 정승태 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 김진호 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 최경백 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 강선경 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 조대현 (식품의약품안전청, 국립독성연구소 독성부)
  • Published : 2000.12.01
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Abstract

To investigate what kinds effect arsenic exert on the proliferation and differentiation of bone marrow cells to the neutrophilic granulocytes lineage cells, we treated sodium arsenite to murine bone marrow cells without or with the stimulation of G-CSF. When we added the various concentrations oj sodium arsenite to bone marrow cells without the stimulation of G-CSF for I, 3, 5 or 7 days, sodium arsenite did not make an any effect up to 2.5 $\mu\textrm{M}$$\mu\textrm{M}$$\mu\textrm{M}$$\mu\textrm{M}$$\mu\textrm{M}$$m\ell$ of G-CSF was induced by the co treatment of 12.5 $\mu\textrm{M}$

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