Study for Three-months Subacute Toxicity of Water-soluble DDB Derivative in Beagle Dogs

비글개에서 수용성 DDB 유도체의 3개월 반복투여독성에 관한 연구

  • 김민영 (서울대학교 수의과대학) ;
  • 손장원 (서울대학교 수의과대학) ;
  • 신민기 (서울대학교 수의과대학) ;
  • 배미옥 (서울대학교 수의과대학) ;
  • 김정현 (서울대학교 수의과대학) ;
  • 방명주 (서울대학교 수의과대학) ;
  • 최진혁 (서울대학교 수의과대학) ;
  • 김준성 (서울대학교 수의과대학) ;
  • 문전옥 (부산대학교 약학대학)
  • Published : 2000.09.01

Abstract

This study was carried out to evaluate the three months subacute intravenous toxicity of water soluble dimethyl dimethoxy biphenylate derivative (DDB-S), a newly formulated therapeutic agent for hepatitis, in Beagle dogs. Groups of 12 male and 12 female dogs were given different dosage of DDB-S, 10 mg/kg/day (high dose group), 5 mg/kg/day (middle dose group), 2.5 mg/kg/day (low dose group) and 0 mg/kg/day (control group) for three months by intravenous route. 1n the three months intravenous toxicity study, there were neither dead animals nor significant changes of body weights during the experimental period. 1n addition to, no significant DDB-S related changes were found in clinical signs, urinalysis and other findings. Statistical changes were observed in hematological. biochemical, partial thromboplastin time (PIT) and organ weight parameters of treated groups. However, these alteration had no relationship with dosage. No histopathological lesions were observed in both control and treated animals. Above data suggest that no observed adverse effect level of test materials in Beagle dogs might be over 10 mg/kg/day in this study.

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