Journal of Nutrition and Health

  • 제33권1호
  • /
  • Pages.80-85
  • /
  • 2000
  • /
  • 2288-3886(pISSN)
  • /
  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

Propolis의 인체 암세포 증식억제 효과에 대한 In Vitro 연구

The Inhibitory Effects of Propolis on In Vitro Proliferation of Human Cancer Cell Lines

  • 이현수 (고려대학교 의과대학 생화학교실) ;
  • 이지영 (고려대학교 한국영양문제연구소) ;
  • 김동청 (고려대학교 한국영양문제연구소) ;
  • 인만진 (청운대학교 식품영양학과) ;
  • 황우익 (고려대학교 의과대학 생화학교실)
  • 발행 : 2000.01.01
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초록

This study was undertaken to investigate the inhibitory effects of propolis on the in vitro proliferation of human colon(HT-29) and hepatoma(HepG2) cancer cell lines. The growth of the HT-29 and HepG2 cells was respectively inhibited by the administration of propolis in a concentration response-dependent manner. The distributions of HT-29 and HepG2 cells cultured in the medium containing propolis were shifted to the smaller sizes, and then HT-29 and HepG2 cells were shrunken under microscopic observations. The progression of cell cycle from G1 to S phase was significantly inhibited by propolis in the HT-29 and HepG2 cell lines, respectively. Those observations suggest that propolis has anticancer effect against some of cancer cell lines in vitro. (Korean J Nutrition 33(1) : 80-85, 2000)

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참고문헌

  1. J Food Sci v.57 no.3 Identification of flavonoids in sunflower honey Sabatier S;Amiot M;Tacchini M;Aubert S
  2. Pharmazie v.40 no.2 Flavonoid content in propolis extracts and growth inhibition of Bacillus subtilis identification off pinocembrine and galangin as antiseptic compounds Pepljnjak S
  3. Contamination and Toxicol v.38 no.2 Polychlorinated biphenyl in honey bees. Bulletin of Environ Morse RA;Culloney TW;Gutenmann WH;Littman CB;Lisk DJ
  4. Biosci Biotechnol Biochem v.56 no.8 Benzyl caffeate, an antioxidative compound isolated from propolis Yamauchi R;Kato K;Oida S;Kamaeda I;Ueno Y
  5. Z Naturforsch C J Biosci v.49 Biochemical activities of propolis-extract. III.Inhibition of dihydrofolate reductase Strehl E;Volpert R;Elstner EF
  6. Cancer Res v.53 Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester Frenkel K;Wei H;Bhimani R;Ye J
  7. Anticancer Res v.16 Effect of a new clerodane diterpenoid isolated from propolis on chemically induced skin tumors in mice Mitamura T;Matsuno T;Sakamoto S
  8. Carcinogenesis v.17 Inhibitory effects of Caffeic acid phenethyl ester(CAPE) on 12-0-teradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells Huang MT;Ma W;Yen P;Xie IG
  9. J Biosci v.44 Antitumor property of ethanolic extract of propolis in mice-bearing Ehrlich carcinoma, as compared to bleomycin Schller S;Knol W;Swiacik J;Owczrek S;Gabrys J;Shani J
  10. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated Grunberger D;Banerjee R;Eisinger K;Oltz EM;Efros L;Caldwell M;Estevez V;Nakanishi K
  11. Semin Oncol v.16 Cancer chemotherapy in the elderly Walsh SJ;Begg CB;Carbone PP
  12. Ann Intern Med v.102 Cancer in the elderly: Basic science and clinical aspects Lipschitz DA;Goldstein S;Reis R;Weksler ME;Bressler R;Neilan BA
  13. Cancer v.60 Intensive treatment of acute leukemia in adults. 70years of age and older Walters RS;Kantarjian HM;Heating MJ;Estey EH;McCredie KB;Freireich EJ
  14. Cancer Res v.43 Age dependence of the early-phase pharmacokinetics of doxorubicin Robert J;Hoerni B
  15. Korean J Nutrition v.23 no.2 A study on the cytotoxic activity of Galic (Allium sativum) extract against cancer cells (in Korean) Son SH;Hwang WI
  16. Korean J Ginseng Sci v.8 no.2 Effects of petroleum ether extract of ginseng root on some enzyne activity in human colon cancer cells (in Korean) Hwang WI;Oh SK
  17. A study on the growth inhibition of human colon cancer cells by eucommial A study on the growth inhibition of human colon cancer cells by eucommial Hwang WI
  18. Korean J Food Sci Technol v.30 no.1 Effect of Platycodon grandiflorum DC extract on the growth of cancer cell lines(in Korean) Lee JY;Hwang WI;Lim ST
  19. Korean Biochem J v.15 no.3 A study on the pharmacologial activities of korean medicinal herbs. Mainly on the antitumor activities(in Korean) Hwang WI;Lee SD;Oh SK
  20. Korean J Ginseng Sci v.17 no.1 A study on the antitumor activity of Panax ginseng Hwang WI
  21. Korean J Nutrition v.31 no.4 Inhibitory effect of Artemisia princeps Pampan. extract on growth of cancer cell lines Hwang YK;Kim DC;Hwang WI;Han YB
  22. Natural Product Sciences v.5 no.1 Antitumor effect of mugwort(Artemisia princeps Pampan) in vivo Hwang YK;Kim DC;Hwang WI
  23. J Gnseng Res v.23 no.2 Synergistic effect of Panax ginseng and Cinnamoum bume mixture on the inhibition of cancer cell growth in vitro(in Korean) Chung HR;Lee JY;Kim DC;Hwang WI
  24. Culture of human cancer cells(1st ed.) Ohoshi A;Sugeno HG