YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Renal Denervation and Glibenclamide, a selective ATP-sensitive $K^+$ Channel Blocker, on Renal Action of BRL 34915, a ATP-sensitive $K^+$ Channel Opener, in Dog

$K^+$ Channel 개방제인 BRL 34915의 신장작용에 대한 신장 신경제거 와 선택성 ATP-의존성 $K^+$Channel 차단제인 Glibenclamide의 영향

  • Published : 2000.08.01
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Abstract

In anesthetized dogs, antidiuretic action of intravenously administered BRL 34915 (10.0~30.0 $\mu$/kg) was blocked by renal denervation, whereas it was not affected by glibenclamide, a selective $K_{ATP}$ blocker, given into renal artery. Diuretic action in ipsilateral kidney produced by intrarenal administration of BRL 34915 was not influenced by renal denervation, but blocked completely by glibenclamide given into the vein. Above results suggest that the antidiuretic action of BRL 34915 is mediated by renal sympathetic nerves and the diuretic action is caused by opening of $K^+$ channel within kidney.

Keywords

References

  1. J. Cardiovasc. Pharmacol. v.11 Similarities in the mechanism of action of two new vasodilator drugs;Pinancidil and BRL 34915 Cook, N.S.;Quast, U.;Hof, R.P.;Baumlin, Y.;Pally, C.
  2. Br. J. Pharmacol. v.88 Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein Hamilton, T.C.;Weir, S.W.;Weston, A.H.
  3. Br. J. Pharmacol. v.100 The action of diazoxide and minoxidil sulfate on rat blood vessels;a comparison with cromakalim Neugreen, D.T.;Bray, K.M.;McHarg, A.D.;Weston, A.H.;Dutdy, S.;Brown, P.S.;Kay, P.B.;Edwards, G.;Longmore, J.;Southereon, S.
  4. Eur. Heart J. v.14 no.sup. B A Potassium channel opner as momotherapy in chronic stable angina pectories;comparion with placebo Why, H.J.;Richardson, P.J.
  5. Eur. Heart J. v.14 no.sup. B Potassium channel activators in vasospastic angina Why, H.J.;Bauters, C.;McFadden, E.P.;Quandalle, P.;Bertrand, M.E.
  6. Goodman & Gilman's The pharmacological basis of therapeutics(9th Ed.) Hardman, I.G.;Limbird, L.E.;Molinoff, P.B.;Ruddon, R.W.
  7. Research Biochemicals Int. The RBI Hnad Book of Receptor Classification Kebabian, J.W.;Neumeyer, J.L.
  8. 약학회지 v.44 K+ channel 개방제인 BRL 34915의 신장작용 고석태;최홍석
  9. J. Pharmacol. Exp. Ther. v.261 The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in gunjea pig and human airway;Comparison with pinacidil and verapamil Yaylor, S.G.;Arch, J.R.S.;Bond, J.;Buckle, D.R.;Shaw, D.J.;Taylor, J.F.;Ward, J.S.
  10. J. Pharmacol. Exp. Ther. v.250 In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim and their inhibitor by glybenclamide Quast, U.;Cook, N.S.
  11. J. Clin. Invest. v.56 Effects of acute unilateral renal denervation in the rat Elsa, B.R.;Colindres, R.E.;Enrique, P.M.;Muller, R.A.;Gottschalk, C.W.
  12. Quantitative Clinical Chemistry v.2 Methods Phillips, B.A.;Peters;Van Slyke
  13. J. Clin. Invest. v.21 The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man Smith, H.W.;Finkelstein, N.;Aliminosa, L.;Crawford, B.;Graber, B.
  14. Statistical Methods(7th.eds.) Snedecor, G.W.;Cochran, W.G.
  15. Goodman & Gilman's The pharmacological basis of therapeutics(9th Ed.) Hardman, I.G.;Limbird, L.E.;Molinoff, P.B.;Ruddon, R.W.
  16. Physiology of the kidney and body fluids Pitts, R.F.
  17. Am. J. Physiol. v.223 Effect of renal alpha adrenergic stimulation on proximal tubular sodium reabsorption Gill, J.R.,Jr.;Caster, A.G.T.
  18. J. Clin. Invest. v.83 Vasopressin receptor on the principal cells of the rabbit cortical collecting tubule Burnatowska-Hledin, M.;Spielman, W.
  19. Am. Physiol. v.256 Renal microvascular effects of vasopressin and vasopressin antagonists Edwards, R.;Trizna, W.;Kinter, L.
  20. 약제학회지 v.1 닭의 신장기능에 미치는 oxytocin의 영향 고석태
  21. J. Physiol. (Lond.) v.334 The effects of natriuretic atrial extract on renal hemodynamics and urinary excretion in anethetized rats Borenstein, H.B.;Cupples, W.A.;Sonnenberg, H.;Veress, A.T.
  22. Life Sci. v.28 A rapid and potent natriuretic response to intravenous injection of atrial myocadial extract in rats De Bold, A.J.;Borenstein, H.B.;Veress, A.T.;Sonnenberg, H.
  23. Am. J. Physiol. v.232 no.1 Acute unilateral renal denervation in rats with extracellular volume expansion Bello-Reuss, E.;Pastoriza-Munoz, E.;colinders, R.E.
  24. Am. J. Physiol v.229 Renal neuroadrenergic transmision Slick, G.L.;Agilera, A.J.;Zambrack, E.J.;Di Bona, G.F.;Kaloyanides, G.R.
  25. Am. J. Physiol v.232 Effect of acute unilateral renal denervation on tubular sodium reabsorption in the dog Nomura, G.;Takabatake, T.;Arai, S.;Uno, D.;Shimao, M.;Hatfori, N.
  26. Am. J. Physiol. v.171 Hemodynamics and sodium excretion of denervated kidney in anethetized and unanethethized dog Berne, R.M.
  27. J. Pharmacol. Exp. Ther. v.252 Effects of BRL 34915(cromakalim) on renal hemodynamics and function in anesthetized dog Hayashi, K.;Matsumura, Y.;Yoshida, Y.;Ohyama, T.;Hisaki, K.;Suzuki, Y.;Morimoto, S.
  28. J. Pharmacol. Exp. Ther. v.265 unique natriuretic properties of the ATP-sensitive K+ channel blocker glyburide in concious rats Clark, M.A.;Hunphrey, S.J.;Smith, M.P.;Ludens, J.H.
  29. Annu. Rev. Physiol. v.54 Renal pstassium channels and their regulation Wang, W.;Sackin, H.;Geibisch, G.
  30. Am. J. Med. v.70 The pharmacology of sulfonylurea Skilman, T.G.;Feldman, J.M.
  31. J. Pharmacol. Exp. Ther. v.259 Characterization of sulfonylurea receptors and the action of potassium channel openers on cholinergic neurotransmission in guinea pig isolated small intestine Zini, S.;Ben-Ari, Y.;Ashcroft, M.L.