약학회지 (YAKHAK HOEJI)

  • 제44권4호
  • /
  • Pages.318-324
  • /
  • 2000
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

아졸을 포함하는 신규 세파로스포린 유도체의 합성 및 항균력

Synthesis and Antibacterial Activities of Some Azole Containing Cephalosporin Derivatives

  • 발행 : 2000.08.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

9 New cephalosporin derivatives were synthesized and screened for antibacterial activities against various bacteria. (6R,7R) -7$\beta$-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(fluoromethoxyimino)acetamido]-3-[(2-hydroxycarbamoyl)-s-triazolo[1,5-a]-pyrimidin-7-yl]thiomethyl]-3-cephem-4-carboxylic acid sodium salt (compound 3) showed 2 fold enhanced in vitro activity against P. aerurginosa, compared to ceftazidime.

키워드

참고문헌

  1. The Journal of Antibiotic v.48 Structure-Activity Relationships within a Series of C(7)-substituted oxyiminocephalosporins containing the C(3)-methylamino pyridiniumthiomethyl substituent synthesis and biological properties of BRL 57342 and some Analogues Adams, R.G.;Brain E.G.;Branch, A.W.;Harrington, F.P.;Mizen, L.;Neale, J.N.;Zomaya, I.I.
  2. The Journal of Antibiotic v.36 Cephalosporin antibiotics, Synthesis and Antimicrobial activity of 7,3[2-5-Amino-1,2,4,-thiadiazol-3-yl)-2-oxyiminoacet amido] cephalosporin derivaties Csebodes, B.W.;Tosch, M.W.
  3. The Journal of Antibiotic v.51 Discovery of MC-02331, a new cephalosporin exhibiting potent activity against Methicillin-resistant Staphylococcus aureus Hecker, S.J.;Cho, I.;Glinka, T.W.;Zhijia, Z.J.;Price, M.E.;Lee, V.J.;Christensen, B.G.;Ludwikow, M.;David, K.M.;Williams, R.
  4. The Journal of Antibiotic v.48 Studies on new catechol-containing cephalosporins Ⅱ. Synthesis and Structure-Activity Relationships of Cephalosoprin having a catechol moiety at the C-7 position Kyung, I.C.;Cha, J.H.;Pae, A.N.;Cho, Y.S.;Kang, H.;Koh, H.Y.;Chang, M.H.
  5. Patent EP 0286 144
  6. Patent EP 0544 166
  7. The Journal of Antibiotic v.40 Semisynthetic-β-lactam antibiotics Ohi, N.;Aoki, B.;Kuroki, T.;Matsumoto, M.;Kojima, K.;Nehashi, T.
  8. Patent GB 2 053 896A
  9. Patent USP 4 956 462
  10. 대한민국 특허:출원번호 95-44287