Archives of Pharmacal Research
- Volume 23 Issue 3
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- Pages.222-225
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Biological Activity of Conformationally Controlled 2-PAM Derivatives
- Jahng, Yurng-Dong (College of Pharmacy, YeungNam University) ;
- Park, Jae-Gyu (College of Pharmacy, YeungNam University) ;
- Yoo, Jung-Whey (College of Pharmacy, YeungNam University) ;
- Kim, Sun-Young (College of Medicine, Taegu Hyosung Catholic University) ;
- Kim, Tae-An (College of Medicine, Taegu Hyosung Catholic University) ;
- Yang, Jae-Ho (College of Medicine, Taegu Hyosung Catholic University)
- Published : 2000.06.01
Abstract
A series of conformationally controlled 2-PAM derivatives were prepared from 2-acetylpyridine and 2,3-pyrido[b]cycloalkenones in two steps and their reactivities towards parathion poisoned AChE were evaluated. The most planar 2,3-pyrido[b]cyclohexanone oxime methiodide showed an activity comparable to 2-PAM Implying E-syn is that the most active comformation of 2-PAM in the biological system.
Keywords
- 2-PAM;
- Acetylcholine esterase(AChE);
- Parathion;
- 2,3-Pyrido[b]cyclohexanone oxime methiodide;
- 2,3-Pyrido[b]cycloheptanone oxime methiodide;
- 2,3-Pyrido[b]cyclooctanone oxime methiodide