The Reversible Contraction on Relaxation of Isolated Rat Aorta

흰쥐의 대동맥 이완반응에 대한 재수축효과

  • 김진학 (중앙대학교 약학대학 약물학교실) ;
  • 신창열 (중앙대학교 약학대학 약물학교실) ;
  • 박조영 (중앙대학교 약학대학 약물학교실) ;
  • 민영실 (중앙대학교 약학대학 약물학교실) ;
  • 최경범 (중앙대학교 약학대학 약물학교실) ;
  • 염지현 (중앙대학교 약학대학 약물학교실) ;
  • 이남인 (중앙대학교 약학대학 약물학교실) ;
  • 김학림 (중앙대학교 약학대학 약물학교실) ;
  • 손의동 (중앙대학교 약학대학 약물학교실)
  • Published : 2000.06.01

Abstract

TEA, glibenclamide, L-NAME and SKF 525A-induced reversible contraction were investigated using acetylcholine, sodium nitroprusside (SNP) and pinacidil in rat abdominal and thoracic aorta. Acetylcho-line, SNP or pinacidil produced in a dose dependent manner relaxation on phenylephrine-induced contraction In rat aorta. TEA, SKF 525A, and L-NAME produced reversible contractions on acetylcholine-induced relaxation, but not on SNP- or pinacidil-induced relaxation. Glibenclamide significantly produced reversible con- traction on pinacidll-induced relaxation. The reversible effect of TEA on the acetylcholine-induced relaxation was reduced by SKF 525A. These results indicate that the acetylcholine-induced relaxation may be mediated by NO, cytochrome P$_{450}$-dependent epoxygenase pathway, or $Ca^{2+}$ activated $K^{+}$ channel, and the pinacidil-induced relaxation may be mediated by ATP-sensitive $K^{+}$ channel.annel.

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