International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
권호 표지

Studies on PVA/Chitosan/Fibroin Blend Sponge Sheets: Preparation and Wound Healing Effects in Rats

  • Yeo, Joo-Hong (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology) ;
  • Lee, Kwang-Gill (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology) ;
  • Lee, Heui-Sam (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology) ;
  • Lee, Yong-Woo (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology) ;
  • Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyunghee University)
  • Published : 2000.09.01
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Abstract

The preparation of PVA/Chitosan/Fibroin (PCF)-blended sponge sheets and wound healing effects of these sheets in rats were investigated. We excised the skin off rat, including the dermis, approximately 2${\times}$2 cm in size. The wound was coveted with PCF-blended spongy sheets. The spongy sheets absorbed the exudate, and gained flexibility and softness. Histopathological inspection of the wound 12 days later showed the increase of a vascular ingrowth and the absence of inflammatory cells. Regeneration of the skin around the wound was faster than that of the control. We also tested wound healing effects of PVA, Chitosan and Fibroini alone of in various combinations. Wound healing was accelerated in the order of PVA/chitosan/Fibroin (PCF)-blended sponge>Chitosan/Fibroin (CF)-blended sponge$\geq$Fibroin (F) sponge>PVA/Chitosan-blended sponge (PC)>Chitosan (C) sponge.

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