Propofol이 개의 뇌파에 미치는 영향

Effects of Propofol on Electroencephalogram in Dogs

  • 장환수 (경북대학교 수의과대학) ;
  • 장광호 (경북대학교 수의과대학) ;
  • 채형규 (경북대학교 수의과대학) ;
  • 권은주 (경북대학교 수의과대학) ;
  • 김정은 (경북대학교 수의과대학)
  • 발행 : 2000.12.01

초록

The aim of this study was to evaluate the effects of propofol on cortical electroencephalogram (EEG) in seven dogs. Propofol infusion was accomplished from low concentration to high concentration in series, and each concentration was infused for 20 minutes (M0: 0, M0.5: 0.5, M1.0:1.0, and M1.5: 1.5 mg/kg/min of infusion rate). EEG was recorded via needle electrode placed at Cz, which was applied to International 10-20 system. Arterial blood pressure. blood gas analysis and ECG were also measured. Hoemodynamics, Pa$CO_2$, PaO$_2$, heart rate and respiratory rate were variable, but were net significant(p>0.05). The power spectra of EEG in every concentration was compared wish those of control (MO). The powers at a1l frequencies at M1.0 and Ml.5 were decreased. Especially, the powers of the frequencies over 20 Hz were significantly decreased (p<0.O5). Powers at frequencies between 8 and 15Hz at MO.S were significantly increased (p<0.05) in response to the painful stimuli. It was inferred that they may reflect activity of the brain which is consciously processing the external Stimuli. Like the Power spectra, al1 the band powers of He EEG ($\delta$ 1-4, $\theta$4-8, $\alpha$ 8-13, $\beta$L13-21. $\beta$H 21-30, \ulcorner 30-50, and total 1-5OHz) were decreased in proportion to the increase of infusion rate at M1 .0 and M1.5. Especially, decrease of $\beta$H and ${\gamma}$ were significant(p<0.01). At M0.5, $\alpha$ band was significantly increased(p<0.05) among all the bands. Seizure activities which were concide with occurrence of spike wave were shown in all dogs at Ml .0 and M1.5.

키워드

참고문헌

  1. Arch.Psychiatr.Nervenkr v.87 Uber das Elecktrenkephalogramm des Menschen Berger H
  2. Am J Vet Res v.58 Evaluation of selected cardio-pulmonary and cerebral response during medeto-midine,propofol, and halothane anesthesia for laparoscopy in dogs Bufalari A;Short CE;Giannoni C;Pedrick TP;Hardie RJ;Flanders JA
  3. British Med J v.2 The electrical currents of the brain Caton R
  4. The Journal of Pediatrics v.113 Neonatal neurologic and electro-encephalographic effects of intrauterine cocaine exposure Doberzak TM;Shanzer S;Senie RT;Kandall SR
  5. JAVMA v.202 Tail chasing in a Bull Terrier Dodman NH;Bronson R;Gliatto J
  6. JAVMA v.201 Phenobarbital-responsive episodic dyscontrol(rage)in dogs Dodman NH;Miezek KA;Knowles K;Thalhammer JG;Shuster L
  7. The diagnostic value of the EEG. In: Spehlmann's EEG primer (2nd ed) Fisch BJ
  8. Science v.239 Neurometrics: Computer-assisted differential diagnosis of brain dysfunctions John ER;Prichep LS;Fridman J;Easton P
  9. Anesthesiology v.88 Electroencephalographic derivatives as a tool for predicting the depth of sedation and anesthesia induced by sevoflurane Katoh T;Suzuki A;Ikeda K
  10. Veterinary Surgery v.22 Cardiovasucular effects of a continuous two-hour propoful infusion in dogs Keegan RD;Greene SA
  11. Am J Vet Res v.54 Antagonism by flumazenil of midazolam-induced changes in quantitative electroencephalographic data from isoflurane-anesthetized dogs Keegan RD;Greene SA;Moore MP;Gallagher LV
  12. Korean J Physiol Pharmacol v.3 Electroencephalographic correlation dimension changes with depth of halothane Lee MG;Park EJ;Choi JM;Yoon MH
  13. Anesthesiology v.84 Prediction of movement during propofol/nitrous oxide anesthesia Leslie K;Sessler DI;Smith WD;Larson MD;Ozaki M;Blanchard D;Crankshaw DP
  14. Anesth Analg v.69 A comparison of EEG determinants of near-awakening from isoflurane and fentanyl anesthesia Long CW;Shah NK;Loughlin C;Spydell J;Bedford RF
  15. Am J Vet Res v.52 Quantitative electroencephalography in dogs ancsthetized with 2.0% end-tidal concentration of isoflurane anesthesia Moore MP;Greene SA;Keegan RD;Gallagher L;Gavin PR;Kraft SL;Deltaan C;Klappenbach K
  16. Veterinary Record v.124 Clinical evaluation of propofol as an intravenous anaesthetic agent in cats and dogs Morgan DWT;Legge K
  17. British Journal of Anesthesia v.70 Pharmacokinetics of propofol administered by infusion in dogs undergoing surgery Nolan A;Reid J
  18. Veterinary Surgery v.20 Electroencephalographic power spectrum analysis as a monitor of anesthetic depth in horses Otto K;Short CE
  19. Veterinary Drug Handbook(3rd ed) Plumb DC;Pharm D
  20. Anesthesiology v.67 Changes in EEG spectral edge frequency correlate with the hemodynamic response to laryngoscopy and intubation Rampil IJ;Matteo RS;
  21. Am J Vet Res v.53 Cardio-pulmonary,anesthetic, and postancsthetic effect of introvenous infusions of propoful in Greyhounds and non-Greyhounds Robertson SA;Johnston S;Beemsterboer J
  22. Anesthesiology v.77 Pancuronium increases the duration of electroencephalogram burst suppression in dogs anesthelized with isoflurane Schwartz AE;Navedo AT;Berman MF
  23. Anesth Analg v.84 multicenter study of bispectral electrocephalogram analysis for monitoring anesthetic effect Sebel PS;Lang E;Rampil IJ;White PF;Cork R;Jopling M;Smith NT;Glass PSA;Manberg P.A
  24. Vet Clin North Am Small Anim Pract v.29 Propofol anesthesia Short CE;Burfalari A
  25. Anesth Analg v.81 Electroencephalographic characteristics of emergence from propofol/sufentanil total intravenous anesthesia Traast HS;Kalkman CJ
  26. 경대외대지 v.32 흰쥐 뇌파에 미치는 Halothane 마취효과의 정량적 분석 박성근;이만기
  27. 한국 응용약물학회지 v.7 흰쥐 대뇌피질의 뇌파에 대한 diazepam 및 flumazenil 의 약력학적 상호작용 이만기
  28. 한국 응용약물학회지 v.8 중추성 약물의 뇌파 효과의 정량화를 위한 스펙트럼 분석에 필요한 기본적 조건의 검토 임선희;권지숙;김기민;박상진;박진숙;정성훈;이만기