Effects of Resistant Starch on Metabolism of Beile Acids in College Women

효소저항저분이 인체내 담즙산 대사에 미치는 영향

  • 김지현 (전남대학교 가정대학 식품영양학과) ;
  • 최인선 (전남대학교 가정대학 식품영양학과) ;
  • 박소앙 (전남대학교 가정대학 식품영양학과) ;
  • 신말식 (전남대학교 가정대학 식품영양학과) ;
  • 오승호 (전남대학교 가정대학 식품영양학과)
  • Published : 2000.12.01

Abstract

The purpose of this study was to examine the effect of resistant starch(RS) in hyperchlesterolemia and colon cancer. The subjects of this study was eight college women participating in the general starch diet(GSD) period for 5 days and resistant starch diet(RSD) period for 7 days. RSD contains 30g or the RS. On the last day of each program blood were collected. And for the last 3 days of each diet period, the amount of all the food consumed by the subjects and feces were collected. Food was measured to determine and compared the energy, protein and fat intakes. The amount of total cholesterol, HDL-cholesterol, LDL-cholesterol and volatile fatty acids in plasma and the amounts of bile acids in feces were measured by gas chromatography. The results obtained were as follows, Daily energy intake was higher in the RSD compared with the GSD, Protein and fat intakes were lower in the RSD compared with the compared with the GSD. Volatile fatty acid contents in plasma, the amounts of acetic acid, propionic acid and valeric acid were higher in the RSD compared with the GSD. The amounts of bile acids in feces, cholic acid, chenodeoxycholic acid and lithocholic acid were higher in the RSD compared with the GSD, But the amount of deoxycholic acid n the RSD period was significantly low. Secondary/primary ratios of bile acids was lower in the RSD compared with GSD, respectively. We speculate that , RS consumption decreases colonic mucosal proliferation as a result of the decreased formation of cytotoxic secondary bile acids. Thus, RS intakes may contribute the prevention of heart disease and colon cancer in humans. (Korean J Nutrition 33(8) : 802-812, 2000)

Keywords

References

  1. Annual report on the cause of death statistics National statistical office
  2. '95 National nutrition survey report Ministry of Health and Welfare
  3. Lancet v.2 no.8259 Effect of diet and smoking intervention on the incidence of coronary heart disease. Report from the Oslo Study Group of a randomised trial in healthy men Hjermann I;Velve Byre K;Holme I;Leren P
  4. J Epidemiol & Community Health v.39 no.3 Risk factors for ischaemic heart disease: The prospective phase of the British regional heart study Shaper AG;Pocock SJ;Walker M;Phllips AN;Whitehead TP;Macfarlane PW
  5. Am J Clin Nutr v.50 no.1 Diet and fecal steroid profile in a South Asian population with a low colon-cancer rate Mckeigue PM;Adelstein AM;Marmot MG;Henly PJ;Owen RW;Hill MJ;Thompson MH
  6. Br J Cancer v.52 no.3 Dietary fiber consumption in Britain . new estimates and their relation to large bowel cancer mortality Bingham SA;Williams DR;Cummings JH
  7. Am J Clin Nutr v.28 no.8 Coronary heart disease and dietary fiber Trowell H
  8. Lipids v.26 no.3 Implication of steroid saponin and sapogenins in the hypocholesterolemic effect of fenugreek Sauvaire Y;Ribes G;Baccon JC;Loubatieres-Mariani MM
  9. Am J Gastroenterol v.81 no.10 Dietary fiber: hyperlipidemia, hypertension, and coronary heart disease Anderson JW;Tietyen-Clark J
  10. Am J Clin Nutr v.61 no.2 Chronic oat bran intake alters postprandial lipemia and lipoproteins in healthy adults Dubois C;Armand M;Senft M;Portugal H;Pauli AM;Bernard PM;Lafont H;Lairon D
  11. Am J Clin Nutr v.55 no.1 Effects of oat bran, rice bran, wheat fiber, and wheat germ on postprandial lipidemia in healthy adults Cara L;Dubois C;Borel P;Armand M;Senft M;Portugal H;Pauli AM;Bernard PM;Lairon D
  12. In nutritional value of cereal products, beans and starches Wursch P;Bourne GH (,ed.)
  13. Biochem J v.299 Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces Abadie C;Hug M;Kubli C;Gains N
  14. N Engl J Med v.304 no.15 Incomplete absorption of the carbohydrate in all-purpose wheat flour Anderson IH;Levine AS;Levitt MD
  15. Am J Clin Nutr v.42 no.5 Digestion of the polysaccharides of some cereal foods in the human small intestine Englyst HN;Cummings JH
  16. Gastroenterology v.95 no.2 Starch malabsorption and breath gas excretion in healthy humans consuming low- and high-starch diets Flourie B;Leblond A;Florent C;Rautureau M;Bisalli A;Rambaud JC
  17. Gastoenterology v.103 no.6 Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides(dietary fiber) Cummings JH;Bingham SA;Heaton KW;Eastwood MA
  18. Br J Nutr v.75 no.5 Digestion and physiological properties of resistant starch in the human large bowel Cummings JH;Beatty ER;Kingman SM;Bingham SA;Englyst HN
  19. Br J Nutr v.62 no.1 Effect of some poorly digestible carbohydrates on bile acid bacterial transformations in the rats Andrieux C;Gadelle D;Leprince C;Sacquet E
  20. Lancet v.1 no.8229 High colonic pH promotes colorectal cancer Thornton JR
  21. SAfr Med J v.55 no.13 Fecal pH value and its modification by dietary means in South African black and white schoolchildren Walker AR'Walker BF;Segal I
  22. Lipids v.30 no.9 Resistant starch is more effective than cholestyramine as a lipid-lowering agent in the rat Younes H;Levrat MA;Demigne C;Remesy C
  23. Am J Clin Nutr v.67 no.1 Effects of resistant starch on the colon in healthy volunteers: possible implications for cancer prevention Hylla S;Gostner A;Dusel G;Anger H;Bartram HP;Christl SU;Kasper H;Scheppach W
  24. Lipids v.31 no.10 Effectiveness of resistant starch, compared to guar gum, in depressing plasma cholesterol and enhancing fecal steroid excretion Levrat MA;Moundras C;Younes H;Morand C;Demigne C;Remesy C
  25. Formation and characteristics of enzyme resistant starch from maize starches with different amylose contents Mun SH
  26. J Assoc Anal Chem v.68 Total dietary fiber in foods, enzymetic gravimetric method, First action American Association of Official Analytical Chemical Change in Method
  27. Br J Nutr v.13 A Ballistic Bomb Calorimeter Miller DS;Payne PR
  28. Nutrition: an integrated approach (3rd Ed.) Pike RL;Brown ML
  29. Recommended dietary allowances for Koreans (6th revision) The Korean Nutrition Society
  30. J Lipid Res v.6 Quantitative isolation and gaslipid chromatographic analysis of total fecal bile acids Grundy SM;Ahrens EH;Miettinen TA
  31. J Lipid Res v.6 Quantitative isolation and gasliquid chromatographic analysis of total dietary and fecal netural steroids Miettinen TA;Ahrens EH;Grundy SM
  32. Am J Clin Nutr v.55 no.2 Physical properties of dietary fiber that influence physiological function: a model for polymers along the gastrointestinal tract Eastwood MA;Morris ER
  33. J Lipid Res v.33 no.8 Effects of psyllium hydrophilic mucilloid on LDL-cholesterol and bile acid synthesis in hypercholesterolemic men Everson GT;Daggy BP;McKinley C;Story JA
  34. J Nutr v.124 no.8 Dietary psyllium hydrocolloid and pectin increase bile acid pool size and change bile acid composition in rats Matheson HB;Story JA
  35. Am J Gastroenterol v.81 no.10 Dietary fiber: hyperlipidemia, hypertension, and coronary heart disease Anderson JW;Tietyen-Clark J
  36. Am J Clin Nutr v.61 no.2 Chronic oat bran intake alters postprandial lipemia and lipoproteins in healthy adults Dubois C;Armand M;Senft M;Portugal H;Pauli AM;Bernard PM;Lafont H;Lairon D
  37. Am J Clin Nutr v.55 no.1 Effects of oat bran, rice bran, wheat fiber, and wheat germ on postprandial lipemia in healthy adults Cara L;Dubois C;Borel P;Armand M;Senft M;Portugal H;Pauli AM;Bernard PM;Lairon D
  38. Am J Clin Nutr v.61 no.4 Resistant starch in the diet increases breath hydrogen and serum acetate in human subjects Muir JG;Lu ZX;Young GP;Cameron-Smith D;Collier GR;O'Dea K
  39. Gut v.28 no.10 Short chain fatty acids in human large intestine, portal, hepatic and venous blood Cummings JH;Pomare EW;Branch WJ;Naylor CP;Macfarlane GT
  40. Gastroenterology v.90 no.1 Colonic metabolism of wheat starch in healthy humans. Effects on fecal outputs and clinical symptoms Flourie B;Florent C;Jouany JP;Thivend P;Etanchaud F;Rambaud JC
  41. Digestive Diseases & Sciences v.39 no.4 Effect of resistant starch on colonic fermentation, bile acid metabolism , and mucosal proliferation van Munster IP'Tangerman A;Nagengast FM
  42. Gut v.33 no.9 Portal and peripheral blood short chain fatty acid concentrations after caecal lactulose instillation at surgery Peters SG;Pomare EW;Fisher CA
  43. J Natl Cancer Inst v.70 no.2 Differential susceptibility of AKR, C57BL/6J. and CF1 mice to 1,2-dimethylhydrazine-induced colonic tumor formation predicted by proliferative characteristics of colonic epithelial cells Deschner EE;Long FC;Hakissian M;Hermann SL
  44. Br J Nutr v.75 no.5 The relationship to dietary fiber intake and fecal bile acid profiles Hwang EH
  45. Cancer Res v.49 no.16 Biochemical epidemiology of colon cancer: effect of types of dietary fiber on fecal mutagens, acid, and neutral sterols in healthy subjects Reddy B;Engle A;Katsifis S;Simi B;Bartram HP;Perrino P;Mahan C
  46. Steroids v.32 no.2 Effect of pH on bile salt degradation by mixed fecal culture Macdonald IA;Singh G;Mahony DE;Meier CE
  47. Comp Biochem Physiol(B) v.70B The effect of cecectomy on fecal bile acid and neutral steroid excretion of the rat Okhyusen-Young C;Kellog TF
  48. J Lipid Res v.21 no.2 Effect of cecum and appendix on 7 alpha-dehydroxylation and 7 beta-epimerization of chenodeoxycholic acid in the rabbit Yahiro K;Setoguchi T;Katsuki T
  49. J Nutr Sci Vitaminol(Tokyo) v.28 Eicosapentaenoic acid of serum lipids of japanese islander with low incidence of cardiovascular diseases Kazawa Y;Niskizawa M;Suzuki M