Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
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Tertiary Structure of PreSl(21-47) of Hepatitis B Virus Studied by NMR Spectroscopy

  • Kyeunghee Yu (Department of Chemistry, Konkuk University) ;
  • Cho, Eun-Wie (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Shin, Song-Yub (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Kol-Lyong (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Yangmee (Department of Chemistry, Konkuk University)
  • Published : 2000.02.01
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Abstract

To design more efficient peptide antagonist against the HBV, preSl(21-47) which carries the HBV receptor binding site for hepatocytes was synthesized and the solution structure of preSl(21-47) was investigated using CD spectroscopy and NMR spectroscopy in membrane-mimicking environments. According to CD spectra, preSl(21-47) has a random structure in aqueous solution, while conformational change was induced by addition of TFE and SDS micelle. Tertiary structures as determined by NMR spectroscopy shows that preSl(21-47) has a very flexible structure even in SDS micelle.

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