Comparative Anesthetic Effect as Propofol Infusion Rate During Maintenance of Anesthesia in Dog

개에서 Propofol 점적투여율 변화에 따른 마취효과

  • 장광호 (경북대학교 수의과대학) ;
  • 임재현 (경북대학교 수의과대학) ;
  • 장인호 (경북대학교 수의과대학)
  • Published : 2000.06.01

Abstract

To evaluate anesthetic effecto of propofol infusion after premedication with xylazine, 20 days were randomly assigned 4 groups. Propofol was infused (group 1: 0.2 mg/kg/min, group 2 : 0.4 mg/kg/min, group 3 : 0.6 mg/kg/min, group 4 : 0.8 mg/kg/min) for a period of 90 minute immediately after premedication with xylazine(1 mg/kg) and atropine(0.05mg/kg) under oxygen supplementation. Induction of anesthesia was rapid and smooth providing satisfactory conditions for intubation in all the dogs. No vomiting and cyanosis were observed after induction and during propofol infustion. There was pain reflex in group 1 but not in group 3 and 4. Mean arousal times (mins) were $6.18{\pm}3.65(group 1), 13.07{\pm}5.05(group 2), 22.06{\pm}6.48(group 3) and 23.33{\pm}9.28 (group 4) and Mean walking times were 16.20{\pm}6.15(group 1), 15.80{\pm}4.73(group 2), 28.27{\pm}7.55 (group 3), 39.10{\pm}13.75$ (group 4) respectively. In group 4, body temperature during total infusion period in group 3, 4. Hematologic values (WBC, RBC, PCV) and serum chemistry values(ALT, AST, BUN, creatinite) were monitored before anesthesia, 1 hour and 1 day after termination of infusion postanestesia. No significant changes were monitored in all experimental group. Although propofol infusions of 0.2 mg/kg/min and 0.4mg/kg/min were considered too low to maintain a suitable depth of anesthesia, but that of 0.6mg/kg/min were considered too low to maintain a suitable depth of anesthesia, but that of 0.6mg/kg/min proper to provide a light planes for minor surgical procedure during 90 minutes with xylazine premedication.

Keywords

References

  1. Laboratory Animal Science v.43 propofol in rabbits 2. Long-term anesthesia Aeschbacher G;Webb AE
  2. Acta vet Scand v.37 Comparative responses to propofol anaesthesia alone and with а₂adrenergic medication in a canine model Bufalari A;Short CE;Giannoni C;Vainio O
  3. Anesthesiology v.79 Effect of propofol infusion on splanchnic hermodynamic and liver oxygen consumption in the Rat. Carmichael FJ;Crawford MW;Khayyam N;Saldivia V
  4. British Journal of Anaesthesia v.60 Hemodynamic changes during anaesthesia induced and maintained with propofol Claneys MA;Gepts E;Camu F
  5. The Veterinary Record v.140 Effects of tiletamine/zolazepam premedication on propofol anaesthesia in dogs Cullen LK;Reynoldson JA
  6. British Journal of Anaesthesia v.69 Propofol anticonvulsant activity in experimental epileptic status De Riu PL;Petruzzi V;Testa C;'Mulas M;Melis F;Caria MA;Mameli O
  7. British Journal of Anaesthesia v.64 Study of the possible interaction between fentanyl and propofol using a computer controlled infusion of propofol Dixon J;Roverts FL;Tackley RM;Lewis GTR;Connel H;Prys-robers C
  8. Am J Vet Res v.58 Cardiopulmonary effects of propofol infusion in llama Duke T;Egger CM;Ferguson JE;Frketics MM
  9. Journal of Small Animal Practice v.37 Romifidine as a premedicant to propofol induction and infusion anaesthesia in the dog England GCW;Andrews F;Hammard RA
  10. JAVMA v.211 Use of propofol-isoflurane as an anesthetic regimen for cesarean section indogs Funlquist PME;Nyman GC;L Fgren AJ;Fahlbrink EM
  11. Anesth Analg v.66 Disposition of propofol administered as constant rate intravenous infusions in humans Gepts E;Camu F;Cockshott ID;Douglas EJ
  12. British Journal of Anaesthesia v.63 Cardiovascular effects of propofol in the anaesthetized dog Goodchild CS;Serrao JM
  13. Anaesthesia v.40 The haemodynamic effects of intravenous induction Grounds RM;Twigley AJ;Carli F;Whitwam JG;Morgan M
  14. Journal Small Anim Pract v.28 A clinical trial of propofol infusion anaesthesia in dog Hall LW;Chambers JP
  15. Journal of Veterinary Anaethesia v.21 The effect on medetomidine premedication upon and propofol induction and infusion anaesthesia in dog Hammand RA;England GC
  16. The Veterinary Record v.24 Medetomidine as a premedicant for ketamine, propofol or fentanyl anaesthesia in dogs Hellebrekers LJ;Sap R
  17. Am J Vet Res v.53 Cardio-Vascular and respiratory effects of propofol administration in hypovolemic dogs Ilkiw JE;Pascoe PJ;Haskins SC;Patz JD
  18. Veterinary Surgery v.24 The effects of consecutive day propofol anaesthesia on feline red blood cells Jacqueline LA;Thomasn KD;Deborah GD
  19. Anaesthesia, Veterinary Surgery v.22 Cardiovascular effects of a continuous two-hour propofol infusion in dogs, comparison with isoflurane Keegan RD;Green SA
  20. Drugs v.35 Propofol-a review of its pharmacokinetic properties and use as an intravenous anesthetic Langley MS;Heel RC
  21. Verterinaryb surgery v.26 Anesthesia in sheep with propofol or with xylazine-ketamine followed by halothane Lin HC;Purohit RC;Powe TA
  22. ACTA Anesthesiol Scand v.43 Prolonged dysequilibrium between blood and brain concentration of propofol during infusion in sheep Ludbrook GL;Upton RN;Grant C;Martinez A
  23. Anaesthesia v.42 Propofol for intravenous sedation Mackenzie N;Grant IS
  24. Veterinary Surgery v.24 Evaluation of propofol as a general anesthetic for horses Mama KR;Steffey EP;Pascoe PJ
  25. Am J Vet Res v.56 Effect of chloramphemcol on infusion pharmacokinetics of propofol in greyhounds Mandsager RE;Clark CR;Shawley RV;Hague CM
  26. postgraduate Medical Journal v.61 The induction of anaesthesia with propofol(('Diprivan')compared in normal and renal failure patients Morcos WE;Payne JP
  27. The Veterinary Record v.124 Clinical evaluation of propofol as an intravenous anaesthetic agent in cats and dogs Morgan DWT;Legge K
  28. Anaesthesia v.43 Propofol for induction of anaesthesia in children Morton NS;Wee M;Christie G
  29. British Journal of Anaesthesia v.66 Effect of I.V. anesthesia with propofol on drug distribution and metabolism in the dog Mouton PS;Whelan E;Shay S;Wood AJJ;Wood M
  30. A J Vet Res v.59 Respiratory depression and apnea induced by propofol in dohs Muir IIIWW;Gadawski JE
  31. British Journal of Anaesthesia v.75 Effects of graded infusion rate of propofol on cardiovascular haemodynamic, coronary circulation and myocardial metabolism in dogs Nakaigawa Y;Akazawa S;Shimizu R;Ishin R;Yamato R
  32. British Journal of Anaesthesia v.70 Pharmacokinetics of propofol administrated by infusion in dogs undergoing surgery Nolan A;Reid J
  33. Veterinary Drug Handbood Plumb Donald C
  34. British Journal of Anaesthesia v.69 Effect of graded infusion rate of propofol dog Puttick RM;Kiederricks J;Sear JW;Glen JB;Foex P;Ryder WA
  35. A J Vet Res v.59 Cardiorespiratory and anesthetic effects of propofol and thiopental in dogs Quandt JE;Robinson EP;Rivers WJ;Raffe MR
  36. J Vet Pharmacol Ther v.16 Propofol as an induction agent in the goat. a phamacokinetic study Reid J;Nolan AM;Welsh E
  37. Research in Veterinary Science v.61 Pharmacokinetics of propofol as an induction agent geriatric dogs Reid J;Nolan AM
  38. Am J Vet Res v.53 Cardiopulmonary, anaesthetic, and postanesthetic effects of intravenous infusions of propofol in Greyhounds and non-Greyhounds Robertson SA;Johnston S;Beemsterboer J
  39. Anesthesiology v.71 Propofol : A new intravenous anesthetic Sebel PS;Lowdon JD
  40. Anaesthesia v.65 Pharmacokinetics of propofol infusion in patients with cirrhosis Servin F;Cockshoot ID;Farinotti R;Haberer JP;Winckler C;Desmonts JM
  41. Anesthesiology v.69 Pharmacokinetics and pharmacodynamics of propofol infusion during general anesthesia Shafer A;Doze VA;Shafer SL;White pF
  42. J Am Anim Hosp Assoc v.32 Excitatory movements in a dog following propofol anesthesia Smedile LE;Duke T;Taylor SM
  43. JAVMA v.202 Adverse effects of administration of propofol with various preanesthetic regimens in dogs Smith JA;Gaynor JS;Bednarski RM;Muir WW
  44. Am J. Vet Res v.55 Hemodynamic and analgesic effects of propofol infusion in medetomidine-premedicated dogs Thurmon JC;Ko JCH;John Benson G;Tranquill WJ;Olson WA
  45. Canine Practice v.20 Clinical appraisal of propofol as asn anesthetic in dogs premedicated with medetomidine Thurmon JC;Tranquilli WJ;Ko JCH
  46. Am J Vet Res v.53 Median effective dosage of propofol for anesthesia in dogs Watney GCG;Pabol LS
  47. The Veterinary Record v.23 Induction of anaesthesia in dogs and cats with propofol Weaver BMQ;Raptopoulos D
  48. anesth analg v.68 Clinical uses of intravenous anesthesia and analgesic infusions White PF