Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Histopathological Studies on the Experimental Lead Poisoning in Rats

실험적 납중독 랫드의 조직병리학적 관찰

  • 권오덕 (전북대학교 수의과대학) ;
  • 신태균 (제주대학교 농과대학 수의학과)
  • Published : 2000.06.01
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Abstract

This study was undertaken to find out the effect of lead on histopathological changes in rat. Thirty female Wistar rats, 7 weeks old, were divided into a control and two experimental groups. The control was received normal diet. The two experimental groups were received diets contaminated artificially with 10 or 5,000 ug/g of lead administration group, histopathological changes were observed in the kidney, liver, heat, brain and lung from the 4th week of experiment. Desquamation of renal epithelia and inclusion bodies in the epithelia of renal tubules were demonstrated in the kidneys. But the liver did not show acid-fast inclusion body. Degeneration of cardiac muscles were seen. The number of mast cells were increased in the cardiac muscles. Darkly stained neurons in the cerebral cortex, some inflammatory cells around meningeal vessels and distended Virchow-Robin spaces were observed.

Keywords

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