Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effects of Green Tea Catechin on Renal Dyshunction in Chronic Cadmium Poisoned Rats

만성 카드뮴 중독 쥐의 신장기능 장애에 미치는 녹차 Catechin의 영향

  • Choi, Jeong-Hwa (Department of Food Science and Nutrition, Catholic University of Taegu-Hyosung) ;
  • Park, Keun-Yong (Department of Internal Medicine, School of Medicine, Konyang University) ;
  • Song, Dae-Kyu (Department of Physiology, Keimyung University, School of Medcine) ;
  • Bae, Jae-Hoon (Department of Physiology, Keimyung University, School of Medcine) ;
  • Park, Won-Kyun (Department of Physiology, Keimyung University, School of Medcine) ;
  • Kim, Yong-Jin (Department of Pathology, Medicine Colleage, Yeungnam University) ;
  • Rhee, Soon-Jae (Department of Food Science and Nutrition, Catholic University of Taegu-Hyosung)
  • 최정화 (대구효성가톨릭대학교 식품영양학과) ;
  • 박근용 (건양대학교 의과대학 내과학교실) ;
  • 송대규 (계명대학교 의과대학 생리학교실) ;
  • 배재훈 (계명대학교 의과대학 생리학교실) ;
  • 박원균 (계명대학교 의과대학 생리학교실) ;
  • 김용진 (영남대학교 의과대학 병리학교실) ;
  • 이순재 (대구효성가톨릭대학교 식품영양학과)
  • Published : 2000.10.01
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Abstract

The purpose of this study was to investigate the effects of green tea catechin on renal dysfunction and blood presure change in chronic cadmium poisoned rats. Sprague-Dawley male rats weighing 100$\pm$10g were randomly assigned to one normal group and three cadmium poisoned groups. Cadmium groups were classified to catechin free diet(Cd-0C group) 0.25% catechin diet(Cd-0.25C group) and 0.5% catechin diet(Cd-0.5C group) according to the levels of catechin supplement. Animals were raids for 20weeks. Cadmium were supplied as drinking water of 50ppm Cd2+ Morphological changes shown through a light microscope and an electro-microscope revealed the mitochondria and tubule epithelial cell edema in Cd -0C group but they were alleviated in catechin supplementation. The urinary $\beta$2-microglobulin that measured to observe the glomerular injury were higher in Cd-poisoned groups than in normal group but they was lowered by catechin supplementation. Glomerular filtration ratios(GFR) in Cd-poisoned groups were significantly lower than in normal group but that of catechin supplementation group was similar to normal group. This suggested that catechin protected the kidney from the functional damage. Angiotensin converting enzyme(ACE) activity and blood pressure(BP) in Cd-poisoned groups were significantly higher than in normal group. Heart rate was tended to increase in Cd-poisoned groups. The results indicate that green tea catechin supplementation on chronic cadmium-poisoned rats normalized the renal dysfunction and blood pressure system.

Keywords

References

  1. Cadmium Page AL;Chang AC
  2. Environ Health Perspect v.63 Dietary exposure to cadimium and health effect: impact of environmental changes Piscator M
  3. J Ind Hyg v.14 Cadmium poisoning I. The history of cadmium poisoning and uses of cadmium Prodan LJ
  4. Rep Ser v.505 WHO Tech Joint FAO/WHO Expert committee on Food Additives
  5. Environ Health Perspect v.28 Renal Tubular dysfunction and abnormalities of calcium metabolism in cadmium workers Kazantzis G
  6. Japan J Pharmaccol v.35 no.2 Defense mechanisms against cadmium toxicity. III. Effect of pretreatment with a small oral dose of cadmium on metallothionein synthesis after a large oral dose of cadmium in mice Morita S
  7. Am J Physiol v.214 no.3 Influence of cadmium in renal ischemic hypertension in rats Schroeder HA;Nason AP;Prior RE;Reed JB;Haessler WT
  8. Arch Environ Health v.12 Renal damage after prolonged exposure to cadmium: An experimental study Axelsson B;Piscator M
  9. Isr J Med Sci v.7 no.3 Effect of cadmium in skeletal tissue in normal and calcium-deficient rats Larssen SE;Piscator M
  10. Am J Med v.75 Effect of 1,25-dihydroxyvitamin D₃on calcium and magnesium absorption in the healthy human jejunum and ileum Krejs GJ;Nicar MJ;Zerwekn JE
  11. J Appl Toxicol v.3 no.5 Cadmium-metallothionein-induced nephropathy: A morphological and autoradiographic study of Cadmium distribution, the development tubular damage and subsequent cell regeneration Murakami M;Cain K;Webb M
  12. J Lab Clin Med v.76 no.4 Vascular reactivity and mechanical properties of normal and cadmium-hypertensive rabbits Third GS;Karreman G;Stephan KF;Blakemore WS
  13. J Chronic Dis v.18 Cadmium as a Factor in Hypertension Schroeder HA
  14. Proc Soc Exp Biol Med v.120 no.3 In vitro inhibition of $Na^{+} -K^{+}$ and $Mg^{2+}$?? ATPase by mono, di and trivalent cations Rifkin RJ
  15. J Pharmacol Exp Ther v.200 no.3 Inhibition of renal adenosine triphosphatase by cadmium Nechay BR;Saunsers JP
  16. Experentia v.27 no.8 Cadmium influence on the excretion of sodium by kidneys Lener J;Musil J
  17. Environ Contam Toxicol Bull v.54 no.6 Cadmium concentrations in hu+man renal cortex tissue(Necropsies) Lopez-Antiguez M;CAmean A;Gonzalez G;Repetto M
  18. Environmental Research v.70 Urinary α₁-microglobulin, β₂-microglobulin, and retinol-binding protein levels in general populations in Japan with references to cadmium in urine, blood, and 24-hour food duplicates Ikeda MC;Moon CS;Xhang ZW;Iguchi HI;Watanabe T;Iwami O;Imaj Y;Shimbo S
  19. Toxicollogy and applied pharmacology v.46 Studies on the Disposition of Calcium in Bones of Rats after Continuous Oral Administration of Cadmium Masanori Ando;Yasuyoshi Sayato;Toshiaki Osawa
  20. Korean J. Nutrition v.30 no.3 Effect of Dietary Fibers in Rice and Barey on Lipid and Cadmium Metabolism in the Rat Kim MK;Paek JE
  21. Korean J. Nutrition v.29 no.1 The Effects of Dietary Cu and Fe on the Cd Accumulation in Long-Term Cd Poisoned Rats Kim AJ;Sung CJ
  22. Korean J Nutrition v.25 no.5 The Effect of Dietary Protein and Calcium Levels in Metallothionein and Histopathological Changes during Cadmium Intoxication in Rats Kwan OR;Kim MK
  23. Korean J. Nutrition v.29 no.6 Effect of Dietary Protein Level and Source on Cadmium Intoxification in Rats Kim MK;Seo MS
  24. Korean J. Nutrition v.21 no.6 Effect of Dietary Cadmium and Protein Levels on the Body Protein Metabolism and Cadmium Toxicity in Growing Rats Lee HY;Kim MK
  25. Korean J Nutrition v.29 no.6 Effect of Dietary Cystein Level in Cadmium ad Lead Toxicity in Rats Ryu JM;Kim MK
  26. Korean J Seric Sci v.40 no.1 Effect of Mulberry Leaf Tea for the Removal on Cd and Pb in Drinking Water Kim HB;Lee WC;Kim SY;Lee YK;Bang HS
  27. J Korean Soc Food Nutr v.23 no.5 Effect of Korean Green Tea, Oolong Tea and Black Tea Beverage on the Removal of Cadmium in Rat Kim MJ;Rhee SJ
  28. Korean J Nutrition v.27 no.10 Effect of Korean Green Tea, Oolong Tea and Black Tea beverage on the Antioxidative Detoxification in Rat Poisoned with Cadmium Yoon YH;Rhee SJ
  29. J toxicol Environ Health v.11 Extent of cadmium accumulation and its effect on essential metal in liver, Kidney and body fluids Suzuki KT;Yaguchi K;Ohnuki R;Kishikawa M;Yamada YK
  30. Korean J Nutrition v.26 no.3 Effect of Dietary Selenium of Metallothionein Synthesis and Antioxidative Detoxification Mechanism in Cadmium Administered Rats Rhee SJ;Jun SY
  31. Nippon Nogeikagaku Kaishi v.59 Antioxidative activity of tea leaf catechins Matsuzaki T;Hata Y
  32. J Biophys Biochem Cytol v.9 Improvement in epoxy resin embedding method Lutt JH
  33. J Biophysic Biochem Cytol Staining of tissue sectionss for electron microscopy with heavy metals Watson ML
  34. J Cell Biol v.7 The use of lead citrate at high PH as an electon of aoue stain in electron microscopy Reyonold ES
  35. Clin Chem v.29 no.7 Sensitive colorimetria assay for angiotensin converting enzyme in serum Hugo M;Neels ME;Van Sande;Simon L;Scharpe
  36. Toxicol Appl Pharmacol v.46 The renal toxicity of cadmium metallothionein: Morphometric and X-ray microanalytical studies Flowler BA;Nordberg GF
  37. J of Busan Med Assoc v.18 no.9 Cadmium Toxicity and Platelet Aggregation Hong KW;Lee SW
  38. Korean J of Pharmacology v.20 no.1 A Study of Mechanism Involved in Cadmium-induced Plateelet Aggregation Song CS;Hong KW
  39. J Nat Prod v.50 no.4 Inhibitory effects of various flavonoids isolated from leaves of perimmon on angiotensin-converting enzyme activity Kameda K;Takaku T;Okuda H;Kimura Y;Okuda T;Hatano T;Agata I;Arichi S
  40. Chem Pharm Bull v.27 no.11 Hypotensive principle of diospyros kaki leaves Funayama S;Hikino
  41. Korean J Food Sci Technol v.25 no.3 Inhibition Effect of Against Angiotensin Converting Enzyme of Flavan-3-ols isolated Korean Green Tea Cho YJ;An BJ;Choi C
  42. J Lab clin Med v.46 Concentration of Trace Metals in Urine of Treated and Untreated Hypertensive Patients Compared With Normal Subjects Perry HM Jr;Schroeder HA
  43. Toxicol Appl Pharmacol v.128 no.2 Cadmium uptake by kidney distal convoluted tubule cells Friedman PA;Gesek FA