Biotechnology and Bioprocess Engineering:BBE

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Analytical Techniques for Vancomycin - A Review

  • Avinash P. Sattur (Central Food Technological Research Institute, Mysore, India) ;
  • Lee, Je-Hyuk (Microbial Metabolic Engineering Research Unit, Korea Research Institute of Bioscience and Biotechology, Taejon, Korea, P.O. Box 115, Yusong, Taejon 305-600) ;
  • Song, Ki-Bang (Microbial Metabolic Engineering Research Unit, Korea Research Institute of Bioscience and Biotechology, Taejon, Korea, P.O. Box 115, Yusong, Taejon 305-600) ;
  • T. Panda (Central Food Technological Research Institute, Mysore, India) ;
  • Kim, Chul-Ho (Microbial Metabolic Engineering Research Unit, Korea Research Institute of Bioscience and Biotechology, Taejon, Korea, P.O. Box 115, Yusong, Taejon 305-600) ;
  • Rhee, Sang-Ki (Microbial Metabolic Engineering Research Unit, Korea Research Institute of Bioscience and Biotechology, Taejon, Korea, P.O. Box 115, Yusong, Taejon 305-600) ;
  • B. Gokul (Microbial Metabolic Engineering Research Unit, Korea Research Institute of Bioscience and Biotechology, Taejon, Korea, P.O. Box 115, Yusong, Taejon 305-600)
  • Published : 2000.06.01
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Abstract

Vancomycin belongs to the vancomycin-risocetin family of glycopeptides, and is a subclass of linear sugar containg peptides composed of seven amino acids. Its strochemical configuration forms the basic of a peptidoglycon monomer. The glycosylated hexapeptide chainconsists of chloro-$\beta$-hydroxytyrosines, p-hytidoglycines, N-anthylleucine and aspartic acid forms a rigid molecular frame work and gives the difficulty in the analysis. Voncomycin in the serum samples is usually estimated by liquid chromatography and the bacterial sensitivity was genereally tested by the microbiological assay. The pressent review deals with the qualitative, quantutative, microbioligical and immunological assays and the comparison of the quantitative methods. Clinical implications of vancomycin have also been cited in the review.

Keywords

References

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