Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
권호 표지

Lipopolysaccharide and Prostaglandin $E_2$ regulates the gene expression of IL-1$\beta$ in mouse osteoblast cells

  • Noh, Sang-Ho (Department of Orthodondritics, Kyung-Hee University College of Dental Medicine) ;
  • Park, Young-Gukk (Department of Orthodondritics, Kyung-Hee University College of Dental Medicine) ;
  • Kim, Cheorl-Ho (Department of Biochemistry and Molecular Biology, College of Oriental Medicine)
  • Published : 2000.10.01
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Abstract

Prostaglandin $E_2$(PG$E_2$) is an abundant eicosanoid in bone that has been implicated in a number of pathological states associated with bone loss, and is also known to stimulate matric metalloproteinase-1 systhesis and secretion in rat and human osteoblast cells, although the intracellular reaction remain unclear. Interleukin-1$\beta$ (IL-1$\beta$) is a cytokine that plays a critical role in bone remodelling and appears to act as a downstream effector of most bone-resorbing agents. However, it is still interesting to examine whether PG$E_2$ regulates IL-1$\beta$ expression by mouse osteoblasts or not. Here we demonstrate that PG$E_2$is a potent inducer of IL-1$\beta$ production by fetal osteoblasts.

Keywords

References

  1. Clin. Orthop. v.313 The role of prostaglandin in the regulation of bone metabolism. Kawaguchi, H.;C. C. Pillbeam;J. R. Harrison;L. G. Raiz
  2. J. Clin. Invest. v.56 Prostaglandin-stimulated bone resorption by rheumatoid synovia. Robinson, D. R.;A. H. Tashijan;L. Levine
  3. J. Bone Joint Surg. v.63 Releaes of prostaglandins from bone and muscle after eibial fracture. Dekel, S.;G. Lenthal;M. J. O. Francis
  4. J. Bone Joint Surg. v.63 The treatment of osteomyelitis of the tibia with sodium salicylate. dekel, S.;M. J. O. Francis
  5. Nature v.263 Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins. Galako, C. S. B.;A. Bennett
  6. J. Bone Joint Surg. v.65 The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis. Goldberg, S. R.;A. L. Schiller;M. Roelke;C. M. Rourke;D. A. O'Neil;W. H. Harris
  7. Arch. Biochem. Biophys. v.362 Inhibitory effects of streptozotocin, tumor necrosis-α, and interleukin-1β on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glukokinase. Park, C.;J. R. Kim;J. K. Shim;B. S. Kang;Y. G. Park;K. S. Nam;Y. C. Lee;C. H. Kim
  8. J. Biol. Chem. v.265 Cyclic AMP induces insulin-like growth factor-1 synthesis in osteoblast-enriched cultures. McCarthy,T. L.;M. Centrella;E. Canalis
  9. Endocrinology v.128 Phosphoglandin E2 stimulates insulin-like growth factor I synthesis in osteoblast-enriched cultures from fetal rat bone. McCarthy,T. L.;M. Centrella;L. G. Raisz;E. Canalis.
  10. J. Bone Miner. Res. v.6 Role of prostaglandins in interleukin-1 induced bone resorption in mice in virto. Akatsu, T.;N. Takahashi;N. Udagawa;A. Yamaguchi;K. Sato;N. Nagata;T. Suda
  11. J. Immunol. v.156 Prostaglandin E2 stimulates osteoclast formation via endogenous IL-1β expressed throgh protein kinase A, Amamo, S.;K. Naganuma;Y. Kawata;K Kawakami;S. Kitano;S. Hanazawa
  12. J. Bone Miner. Res. v.3 Further biochemical and molecular characterization of primary rat parietal bone cell cultures. McCarthy, T. L.;M. Centrella;E. Canalis
  13. J. Bone Miner. Res. v.13 Regulation of interleukin-6 production by prostagandin E2 in fetal rat osteoblasts:role of protein kinase A signaling pathway. Millet, I.;T. L. McCarthy;A. Vignery
  14. Endocrinology v.135 Prostanoid-induced expression of matrix mettaloproteinase-1 messenger ribonucleic acid in rat osteosarcoma cells. Clohisy, J. C.;T. J. Connolly;K. D. Bergman;C. O. Quinn;N. C. Patridge