Journal of Life Science
- Volume 10 Issue 1
- /
- Pages.45-47
- /
- 2000
- /
- 1229-1552(pISSN)
Antibacterial Activities of Nonactin from streptomyces viridochromogenes JM-4151
- Lee, Jin-Man (Department of Herb and Food Science, Kyongbuk College of Science, Chilgok-Gun, Kyongbuk, 718-850 Korea) ;
-
Lee, Dong-Sun
;
- Lee, Sang-Han (Biopotency Evaluation Lab, Korea Research Institute of Bioscience and Biotechnology(KRIBB), Taejon 305-333) ;
- Hong, Soon-Duck (Department of Microbiology, College of Natural Sciences, Kyungpook National University, Taegu 702-701) ;
-
Kim, Jong-Guk
(Department of Microbiology, College of Natural Sciences, Kyungpook National University, Taegu 702-701)
- Published : 2000.04.01
Abstract
Nonactin, known as an ionophore antibiotic, was antagonized by the actibity of quercetin, an oxygen radical scavenger. This compound generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was more sensitive than a wild strain, and this hypersensitivity was reduced in the presence of dithiothreitol as an antioxidant. These results suggest that superoxide radical is important in the antibacterial action of this agent.
Keywords