Toxicological Research

  • 제16권1호
  • /
  • Pages.89-94
  • /
  • 2000
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

Guinea pid를 이용한 Glycolic acid 및 UVB의 피부 자극성 평가

Skin Irriation Effect of Glycolic Acid and UVB in Guinea Pig

  • 조대현 (식품의약품안전청, 국립독성연구소) ;
  • 홍진태 (식품의약품안전청, 국립독성연구소)
  • 발행 : 2000.03.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Alpha-hydroxy acid(AHA) are used in cosmetic products as a pH adjuster, mild exfoliant and humectant-skin conditioner. Cosmetics containing higher concentration (30%) and lower pH (3.0) of AHA can cause side effects if it is applied without the prescription. For providing information on the safety of AHA and on human risk assessments we studied skin irritation effect of glycolic acid, one of the most commonly used AHA in guinea pigs. The skin irritation by glycolic acid was increased in a dose(10% to 70%), acidity (pH 2.5 to 5.5.) and length of exposure dependent manner (for up to 14 days), respectively. The combination treatment with UVB (0.4 or 3.0 J/$cm^2$) increased glycolic acid-induced skin irritation. Histological examination showed that hyperplasia of non-inflammatory cells in the epidermis of skin treated with high dose of glycolic acid (pH 3.0). There results show that glycolic acid increased skin irritation in a dose, length of exposure and pH dependent manner, respectively, in guinea pig, and the combination with UVB increased glycolic acid-induced skin irritation. The cell proliferation of non-inflammatory cell may be involved in high doses of glycolic acid-induced skin irritation. Long-term application of more than 30% of glycolic acid (pH 3.0) may cause skin irritation.

키워드

참고문헌

  1. Intern. J. Toxicol. v.17 no.suppl 1 Report of the cosmetic ingredient review expert panel Anderson, F.A.
  2. Dermatol. Surg. v.22 A histological comparison of 50% and 70% glycolic acid peels using solution with various pH Becker, F.F.;Langford, F.P.;Rubin, M.G.;Speelman, P.
  3. Dermatol. Surg. v.22 Round table discussion of alpha hydroxy acid Brody, H.;Coleman Ⅲ, W.P.;Piacquadio, D.;Perricon, N.V.;Elson, M.L.;Harris, D.
  4. Clin. Plas. Surg. v.23 Alpha hydroxy acids in skin care Clark Ⅲ, C.P.
  5. Eur. J. Dermatol. v.6 Population exposure to solar UVA radiation Diffey, B.
  6. J. Am. Acad. Dermatol. v.34 Effects of α-hydroxy acids on photoaged skin: A pilot clinical, histologic, and ultrastructural study Ditre, C.M.;Griffin, T.D.;Murphy, G.F.;Sueki, H.;Telegan, B.;Johson, W.C.;Yu, R.T.;Van scott, E.J.
  7. Clin. Exp. Dermatol. v.8 Ultraviolet radiation of human body sites in relation to occupation and outdoor activity Holman, C.D.J.;Gibson, I.M.;Stephenson, M.;Armstrong, B.K.
  8. Dermatol. Surg. v.25 The effect of glycolic acid on photoaged albino hairless mouse skin. A double-blind vehicle-controlled clinical trial Moon, S.E.;Park, S.B.;Ahn, H.T.;Youn, J.I.
  9. J. Dermatol. Surg. Oncol. v.19 Glycolic acid normal human keratinocyte peels for the treatment of wrinkles and photoaging Moy, L.S.;Murad, H.;Moy, R.L.
  10. J. Dermatol. v.22 Comparison of the effect of various chemical peeling agents in aminipig model Moy, L.S.;Peace, S.;Moy, R.L.
  11. Dermatol. Surg. v.22 Clinical improvement of photoaged skin with 50% glycolic acid. A double-bind vehicle-controlled study Newman, N.;Newman, A.;Moy, L.S.;Bahapour, R.;Harris, A.G.;Moy, R.L.
  12. J. Invest. Dermatol. v.98 Ultraviolet B-irradiated antigen- presenting cells display altered accessory signaling for T-cell activation Simon, J.C.;Elments, C.A.;Krutmann, J.;Bergstresser, P.R.;Cruz, P.D. Jr.
  13. Chem. Biol. Interact. v.122 Protection against 12-O-tetrade-canoylphorbol-13-acetate induced skin hyperplasia and tumor promotion, in a two-stage carcinogenesis mouse model, by the 2,3-dimethyl-6(2-dimethyla-minoetyl)-6H-indole-[2,3-b] quinoxaline analogue of ellipticine Skarin, T.;Rozell, B.L.;Bergman, J.;Toftgard, R.;Moller, L.
  14. Arch. Dermatol. v.132 Topical 8% glycolic acid and 8% L-lactic acid cream for the treatment of photodamaged skin Stiller, M.J.;Bartolone, J.;Stern, R.;Smith, S.;Kollias, N.;Gillies, R.;Drake, L.A.
  15. Clin. Dermatol. v.14 Alpha-hydroxy acids in the treatment of signs of photoaging Vanscott, E.J.;Ditre, C.M.;Yu, R.T.
  16. Toxicol. Sci. v.45 Short-term biomarker of tumor promotion in mouse skin treated with petroleum middle distillates Walborg, E.F.;Conti, C.J.;Slaga, T.J.;DiGionanni, J.;Freeman, J.J.;Steup, D.R.;Skisak, C.M.
  17. Dermatol. Surg. v.23 The effects of glycolic acid on the treatment of acne in Asian skin Wang, C.M.;Huang, C.L.;Hu, C.T.;Chan, H.L.
  18. 새로운 화장품원료 안전성 검토지침 및 독성시험 표준작업지침서 식품의약품안전청