계피나무의 部位別 抗酸化 作用에 關한 硏究(Ⅰ)

Studies on the Effects of the Parts of Cinamomum cassia PRESL on the Antixidation(Ⅰ)

박영준;박용기
Park Ryung-Joon;Park Yong-Gi

  • 발행 : 20000000

초록

The antioxidation effects of Cinnamomi Cortex (CC), Cinnarnomi Ramulus (CR), Cinnamomi Petiole (CP) on the radical scavenging ability from 1,1' -Diphenyl-2-picrylhydrazyl (DPPH), activities of nitrate reductase (NR), superoxide dismutase (SOD), xanthine oxidase and lipid peroxidase (LPO) in rat liver cells were examined In in vitro studies, CR extract had greater DPPH-radical scavenging ability than CC and CP. The NR acitiviry in the cells was more increased by the treatments of CC and CR extracts than CP extract. The enzyme activity of Xanthine oxidase of CC was decreased. Also, levels of lipid peroxidation were proportionally decreased to concentrations of CR. The recovery by CR extract treatment was similar to the level of ascorbic acid treatment. Therefore, it seems that CR extract has similar effects on the antioxidation compared with ascorbic acid, well-known antioxidant. The data indicate that CR has a depressive effect on the production of free radicals and changes in the acitivities of enzymes involved in the antioxidation. Compared to others, CP had smaller effects on the anti oxidation. These results suggest that CR seems to have more potent effects on the antioxidation than other parts of Cinamomum cassia and different mechanisms might be involved in the anitoxidation processes of CC, CP, and CR.

키워드

참고문헌

  1. 中藥大辭典 金昌玟
  2. 本草學 全國韓醫科大學 本草學敎授
  3. 名醫別錄 陶弘景
  4. 草木春秋 張前德;李鐵君;傳雷
  5. 中醫必讀 朱廣仁
  6. 中國藥材學 徐國鈞
  7. 中藥 楊醫亞
  8. 中藥臨床學 王大觀;楊淑芬
  9. 本草綱目 v.3 李時珍
  10. 東垣十種醫書 湯液本草 王好古
  11. 證類本草 唐愼微
  12. 神農本草經疏 繆希雍
  13. 神農本草經 徐樹楠;牛兵占;王辛卵
  14. 中藥心法 程紹恩
  15. 醫學入門 李천
  16. 藥鑒 杜文燮
  17. 醫宗必讀 李中梓
  18. 本草備要 汪昻
  19. 本草從新 吳儀洛
  20. 本草求眞 黃宮繡
  21. 本草易讀 汪認庵
  22. 本草崇原 張志聰
  23. 本草經集注 曹元宇
  24. 神農本草經校注 顧觀光
  25. 神農本草經輯注 馬繼興
  26. 景岳全書 張介賓
  27. 本草綱目合遺 趙學敏
  28. 東醫寶鑑 許浚
  29. 한국식품과학회지 v.25 no.3 용매와 추출조건이 계피추출액의 항산화성에 미치는 영향 김나미;성현순;김우정
  30. 한국식품과학회지 v.25 no.3 에탄올의 농도가 계피 추출액의 지표성분 및 품질특성에 미치는 영향 김나미;성현순;김우정
  31. 慶熙大學校大學院 博士學位論文 桂枝의 芳香性 物質이 家兎의 肝腎 및 循環系 機能에 미치는 影響 梁熙昌
  32. 淑明女子大學校 大學院 博士學位論文 桂皮와 丁香에서 分離한 抗菌活性物質의 食品腐敗微生物 成長抑制效果 李侖徑
  33. 中醫長壽學 王其飛
  34. 中西醫結合雜誌 v.10 no.8 腎虛, 衰老與自由基的關係以及補腎藥對自由基的影響 梁曉春
  35. 中醫雜誌 v.30 no.3 淸宮長春丹對老年腎虛證血漿過기 化脂質高密度脂蛋白膽固醇水平影響的硏究 張文彭
  36. 上海中醫藥雜誌 v.6 祖國醫學抗老年齡問題初探 姚培發
  37. 中醫雜誌 v.30 no.2 老年腎虛證血漿過기化脂質高密度脂蛋白膽固醇及其亞組分水平變化 張文彭
  38. HARRISON'S 내과학 해리슨 번역 편찬위원회
  39. J. Biol. Chem. v.245 A mechanism for the production of ethylene from methional;The generation on the hydroxyl radical by xanthine oxidase Beauchamp, C.;Fridovich, I.
  40. Biochem. J. v.131 Milk xanthine oxidase type D(dehydrogenase) and type O(oxidase) : Purification and interconversion and some properties Batteli, N.G.;Lorenzoni, E.;Stirpe, F.
  41. J. Biol. Chem. v.266 Hydrogen peroxide cause the fatal injury to human fibroblast exposed to oxigen radicals Simon, R.H.;Scogging, C.M.;Patterson, D.
  42. The journal of biological chemistry v.244 no.14 Stirpe, F.;Della Corte, E.
  43. 中醫雜誌 v.30 no.2 老年腎虛證血漿過기化脂質高密度脂蛋白膽固醇及其亞組分水平變化 張文彭
  44. 本草求眞 黃宮繡
  45. 本草易讀 汪認庵
  46. Free radicals, aging and degenerative disease Larry, W.O.;Terry, B.O.
  47. Free radical in biology : Involvement of radical reaction in aging and carcinogenesis in medicinal chemistry Pryor, W.A.
  48. Biochem. Biophys. Res. Comm. v.36 The production of superoxide anion radicals in the reaction of reduced flavins and flavoprotein with molecular oxygen Massey, V.;Strickland, S.;Mayhew, S.G.;Howell, L.G.;Engel, P.C.
  49. Nature v.4617 Antioxidant determination by the use of a stable free radical Blois, M.S.
  50. Eur. J. Bionham. v.47 Involvement of the superoxide anion radical in the antioxibation of pyrogallol and a convenient assay for superoxide dismutase Marklund, S.;Marklund, G.
  51. J. Foo. Sci. v.40 Inhibition of N-nitrosoamine formation in madel food system Gray, J.I.;Dugan, J.L.R.
  52. The journal of biological chemistry v.244 no.14 Stirpe, F.;Della Corte, E.
  53. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction Ohkawa, H.;Ohishi, N.;Yaki, K.
  54. Free radical in biology Involvement of radical reaction in aging and carcinogenesis in medicinal chemistry Pryor, W.A.
  55. The Journal of Pharmacology and Experimental Therapeutics v.220 Levels of acetaminophen and its metabolites in mouse tissues after a toxic does Fischer, L.J.;Green, M.D.;Harman, A.W.
  56. The Journal of Pharmacology and Experimental Therapeutics v.220 Protactive effect of propylthiouacill independent of its hypothyroid effect on acetaminophen toxicity in the rat Raheja, K.L.;Linscheer, W.G.;Cho, C.D.;Mahany, D.
  57. Biochemical Pharmacology v.28 Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo Wendel, A.;Feuerstein, S.;Kontz, K.H.
  58. Thesis of Ph.D in National Fish, Univ. of Pusan Biological actions of maillard reaction products derived from glucose-amino acids Park, J.W.
  59. J. Sci. food Agric v.26 Naturally occuring nitrate/nitrite in food Rorald, W.
  60. Glutathion Flohe, L.;Gunzler, W.A.;Ladenstein, R.;Arias, I.M.(ed.);Jakoby, W.B.(ed.)
  61. Liver and Kidney Burk, R.F.;Lawrence, R.A.;Sies, H.;Wendel, A.(eds.)
  62. Rev. v.3 Methemoglobinemia and methemoglobin producing compounds Bodansky, O.
  63. Free Radic. Biol. Med. v.1 Pathological mechenisems in carbon chloride hepatotoxicity Brattin, W.J.;Glende, E.A.;Recknagel, R.O.
  64. Free Radic. Biol. Med. v.12 Implication of free radical mechanism in cthand induced cellular injury Nordmann, R.;Ribiere, C.;Roach, H.
  65. PNAS v.82 Birnbiom, H.C.;Kanabus, O.;Kominska, M.
  66. J. Biol. Chem. v.257 Autor, A.P.
  67. Biochem. Biophys. Res. Comm. Bilinski, T.;Krawiec, Z.;Litwinska, J.;Blaszezynski, M.