The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Neuroprotective Effects of Acori Graminei Rhizoma on the Brain Ischemia induced by Four-Vessel Occlusion in Rats

석창포(石菖蒲)의 4-VO로 유발한 흰쥐뇌허혈의 신경방어효과

Kim Young-Ock;Kim Young su;Leem Kang-Hyun;Suk Kyoung-Ho;Kim Sun-Ueou;Ju-Young;Ahn Duk-Kyun;Kim Ho-Cheol
김영옥;김영수;임강현;석강호;김선여;박주영;안덕균;김호철

  • Published : 20000000

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Abstract

Acori Graminei Rhizoma(AR, 石菖浦), the rhizome of Acorus gramineus Soland, whose propetty, flavour and channel tropism is pungent in flavour(辛), warm in property(溫), acting on the heart and stomach channels(歸心胃經), has the effects of inducing resuscitation, tranquilizing the mind(開窮安神), resolving dampness, and regulating the functions of the stomach(化濕和胃). This drug is one of the popular drugs in traditional Korean medicine, which has been used to treat loss of consciousness and confusion of the mind(神志昏亂) due to mental disturbance by pathogenic dampness in the course of febrile diseases, and palpitation(心悸), insomina(失眼), amnesia(健忘) and tinnirus(耳鳴) due to insufficiency of the herat-qi. So, this study was planned to check the neuroprotective effect of AR on the global ischemia induced by 4-vessel occlusion in Wistar rats. AR extract was lyophilized after extraction with $70\%$ methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of repel fusion under the cresyl violet staining. The results obtained that in 4-VO ischemia, AR showed significantly neuroprotective effects(1,000 and 500 mg/kg of AR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about $16.8\%,\;13.8\%$ respectively. Consequently, Acori Graminei Rhizoma has neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats.

Keywords

References

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