Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 10 Issue 2
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- Pages.68-73
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- 2000
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Bioequivalence Evaluation of Omeprazole Preparations
오메프라졸을 함유한 울프로정과 로섹캅셀의 생물학적 동등성 평가
- Chi, Sang Cheol (College of Pharmacy, Sungkyunkwan University) ;
- Rhee, Yun Seok (College of Pharmacy, Sungkyunkwan University) ;
- Park, Eun Seok (College of Pharmacy, Sungkyunkwan University)
- Published : 2000.09.01
Abstract
The bioequivalence of two omeprazole preparations was evaluated following their oral administration to 16 normal volunteers. The test product was 'Ulpro tablet' made by Boryung Pharmaceutical Co. and the reference was 'Losec capsule' made by Yuhan Corp. After one capsule or tablet containing 20 mg omeprazole was administered, blood was taken at predetermined time intervals and the concentration of the drug in plasma was determined with an HPLC method. AUC and