Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Studies on the anti-inflammatory action of Taraxacum officinale extract in central nervous system

중추신경계(中樞神經系)에서 포공영(蒲公英)의 항염증작용(抗炎症作用)에 관(關)한 연구(硏究)

  • Go Jae-Yoang (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Kim Tae-Heon (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Kim Jun-Han (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Lyu Yeoung-Su (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University)
  • 고재왕 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김태헌 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김준한 (원광대학교 한의과대학 신경정신과학교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과학교실)
  • Published : 2000.12.01
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Abstract

Substance P(SP) can stimulate production of tumor necrosis factor-${\alpha}$(TNF-${\alpha}$) from astrocytes stimulated with lipopolysaccharide(LPS). The objective of the current study was to determine the effect of Taraxacum officinale(TO) on the production of TNF-${\alpha}$ from primary cultures of rat astrocytes. TO(100& 1000$\mu\textrm{g}$/ml) significantly inhibited the TNF-${\alpha}$ production by astrocytes stimulated with LPS and SP. Interleukin-1(IL-1) has been shown to elevate TNF-${\alpha}$ production from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore examined whether IL-1 mediated inhibition of TNF-${\alpha}$ production from primary astrocytes by TO. Treatment of TO(100 and 1000$\mu\textrm{g}$/ml) to astrocytes stimulated with both LPS and substance P decreased IL-1 production significantly. Moreover, the production of TNF-${\alpha}$ by LPS and substance P in astrocytes was progressively inhibited with increasing amount of IL-1 neutralizing antibody. These results suggest that TO may inhibit TNF-${\alpha}$ production by inhibiting IL-1 production and that TO has an antiinflammatory activity in the central nervous system.

Keywords

References

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