Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Effects of KakamBoyanghwanohTang(KBT) on inhibition of impairment of learning and memory, and acetylcholinesterase in amnesia mice

가감보양환오탕(加減補陽還五湯)이 생쥐의 학습(學習)과 기억(記憶)의 감퇴(減退) 및 Acetylcholinesterase의 억제(抑制)에 미치는 영향(影響)

  • Moon, Sung-Soo (Dept. of Neuropsychiatry, College of Oriental Medicine, Tae Jon University) ;
  • Lee, Sang-Ryong (Dept. of Neuropsychiatry, College of Oriental Medicine, Tae Jon University)
  • 문성수 (대전대학교 한의과대학 신경정신과학교실) ;
  • 이상용 (대전대학교 한의과대학 신경정신과학교실)
  • Published : 2000.09.30
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Abstract

Alzheimer's disease (AD) is progressive neurodegenerative disease, which is pathologically characterized by neuritic plaques and neurofibrillary tangles associated with the acetylcholinesterase, apolipoprotein E and butylcholinesterase, and by mutations in the presenilin genes PS1 and PS2, and amyloid precursor proteins (APPs) overexpression. The present research is to examine the inhibition effect of KBT on PS1, PS2 and APPs overexpression by detected to Western blotting. To verify the Effects of KBT on cognitive deficits further, we tested it on the scopolamine (1 mg/kg)-induced amnesia model of the mice using the Morris water maze tests, and there was ameliorative effects of memory impairment as a protection to scopolamine. KBT only partially blocked the increase in blood serum level of acetylcholinesterase and Uric acid induced by scopolamine, whereas blood glucose level was shown to attenuate the amnesia induced by scopolamine and inreased extracellular serum level compared with only scopolamine injection. In conclusion, studies of KBT that has been know as anti-choline and inhibition ablilities of APPs overexpression, this could also be used further as a important research data for a preventive and promising symptomatic treatment for Alzheimer's disease.

Keywords

References

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