The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of SosokMyeongTang extract on the Regional Cerebral Blood Flow and Blood Pressure in Rats

소속명탕(小續命湯)이 백서(白鼠)의 국소뇌혈류량(局所腦血流量)과 혈압(血壓)에 미치는 영향(影響)

  • Kim, Young-Kyun (Department of 2nd Internal Medicne, College of Oriental Medicine, Dong-Eui University) ;
  • Kwon, Jung-Nam (Department of 2nd Internal Medicne, College of Oriental Medicine, Dong-Eui University) ;
  • Kim, Kyung-Min (Department of 2nd Internal Medicne, College of Oriental Medicine, Dong-Eui University) ;
  • Cho, Eun-Hee (Department of 2nd Internal Medicne, College of Oriental Medicine, Dong-Eui University) ;
  • Park, Ji-Eun (Department of 2nd Internal Medicne, College of Oriental Medicine, Dong-Eui University)
  • 김영균 (동의대학교 한의과대학 심계내과학교실) ;
  • 권정남 (동의대학교 한의과대학 심계내과학교실) ;
  • 김경민 (동의대학교 한의과대학 심계내과학교실) ;
  • 조은희 (동의대학교 한의과대학 심계내과학교실) ;
  • 박지은 (동의대학교 한의과대학 심계내과학교실)
  • Published : 2000.12.30
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Abstract

SosokMyeongTang(SMT) have been used in oriental medicine for many centuries as a therapeutic agent for cerebral disease. The effects of SMT on the vascular system is not known. The purpose of this study was to investigate the effects of SMT on the changes in blood pressure(BP) and regional cerebral blood flow(rCBF) of rats. SMT consists of the following components : Radix Ledebouriellae(防風), Radix Cocculi or Stephaniae(防己), Semen Armeniacae(杏仁), Cortex Cinnamomi(肉桂), Radix Scutellariae(黃芩), Radix Paeoniae Lactiflorae(白芍藥), Radix Ginseng(人蔘), Rhizoma Cnidll(川芎), Herba Ephedrae(麻黃), Radix Glycyrrhizae(甘草), Radix Aconiti(附子?), Fructus Zizyphi Jujubae(大棗), Rhizoma Zingiberis(生薑) and the changes of BP and rCBF were tested Leser-Doppler Flowmetry(LDF) The experimental results were as follows ; BP was not affected by SMT in rats, but rCBF was increased significantly by SMT in a dose dependent manner. SMT increased previous decreasd rCBF due to pretreatment methylene blue, but did not increased previous decreasd rCBF due to pretreatment L-NNA, indomethacin. Pretreatment with indomethacin decreased BP compaired with control group. These results suggest that SMT causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased rCBF is mediated by nitric oxide synthease.

Keywords

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