The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Effect of the methanol extract of Dansameum on the ammonia-induced peptic ulcer in rats

단삼음(丹參飮)이 흰쥐의 소화성 궤양에 미치는 영향

  • Jeon, Chang-Min (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Min, Gun-Woo (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Yoon, Cheol-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kang, Jeong-Jun (Dept. of internal Medicine, Oriental Medicine Hospital, HanSeo Univ.) ;
  • Shin, Uk-Seob (Dept. of Pharmacy, Dongguk Medical Center) ;
  • Kim, Hyung-Jin (Institute of Natural Medicine, Hanseo Univ.) ;
  • Park, Jong-Hyuck (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 전창민 (동국대학교 한의과대학 내과학교실) ;
  • 민건우 (동국대학교 한의과대학 내과학교실) ;
  • 윤철호 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 강정준 (한서대학교 한방병원 내과) ;
  • 신억섭 (동국대학교 의료원 약제과) ;
  • 김형진 (한서대학교 자연요법 연구소) ;
  • 박종혁 (동국대학교 한의과대학 내과학교실)
  • Published : 2000.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : his study was carried out to investigate the effect of Dansameum (DS) on the gastrohemorrhagic lesion induced by ammonia in rats. Methods : Rats were pretreated with DS extract 25 mg/kg for 10 days and then were given amonia through gastric tube. The animals were killed 1 hr after amonia treatment. Results : DS extract siginificantly reduced the gastrohemorrhagic lesion score, the gastric lipid peroxide level, the gastric urease activity, the gastric myeloperoxidase activity, the gastric acid phosphatase activity, xanthine oxidase activity and type conversion, and increased the gastric glutathione level considerably. In photomicrographs of stomach tissue in rat, we could see the gastrohemorrhagic lesion induced clearly. conclusions : These results suggest that DS extract may be effective in peptic ulcer.

Keywords

References

  1. Lancet v.I Unidentified curved bacilli on gastric epithelium in acteve chronic gastritis Marshall, B.J.;Warren, J.R.
  2. Lancet v.I Unidentified curved bacilli in the stomachs of patients with gastritis and peptic ulcerration Marshall, B.J.;Warrin, J.R.
  3. 대한병리학회지 v.29 H. pylori 감염의 병리와 임상 김경미;김호근;이광보;정현채
  4. Can Med Assoc v.140 The prevalence of Campylobacter pylori gastritis among asymptomatic adults Gregon, D.B.;Low, D.E.;Cohen, M.M.;Cooter, J.J.;Wolman, S.L.;Simor, A.E.
  5. Korean language edition v.10 Harrison's principles of internal medicine Kurt J. Isselbacher
  6. 대한미생물학회지 v.23 no.1 위십이지장 염증성 질환에 관한 전향적 연구 이광호(등)
  7. 대한소화기병학회지 v.26 Helicobacter pylori 감염의 진단을 위한 혈청IgG항체가의 유용성 이정호(등)
  8. 대한미생물학회지 v.25 한국인 정상성인의 H. pylori보균율 백승철(등)
  9. Eur J Gastroenterol Hepatol v.4 High dose treatment combined With amoxycillin eradicates Helico bacter pylori Bayerdorffer, E.;Mannes, G.A.;Sommer, A.
  10. Lancet v.337 Duodernal ulcer relapse after eradication Helicobacter pylori Fiocca, R.;Solcia, E.;Santoro, B.
  11. J. Clin. Microbiol v.26 Characterization of urease from campylobacter pylori Mobley, H.L.T.;Cortesia, M.J.;Rosenthal, L.E.;Jones, B.D.
  12. Lancet v.II Campylobacter pyloridis, urease, hydrogen ion back diffusion and gastric ulcers Hazell, S.;Lee, A.
  13. Gastroenterology v.52 Antacid and anticholinergic drug therapy of peptic ulcer Piper, D.W.
  14. N. Eng. J. Med. v.311 Cimetidine, cigarette smoking and recurrence of duodenal ulcer Somtag, S.;Graham, D.Y.;Belsiti, A.;Weiss, J.
  15. N. Eng. J. Med. v.328 Effect of ranitidine and amoxicillin plus metronidazole on the eradication of H. pylori and the recurrence of duodenal ulcer Hentschel, E.
  16. Bockus Gastroenter ology Medical management of uncomplicated peptic ulcer disease Thomson, A.B.R.;Mayai, S.;Berk, J.E.(ed.)
  17. 소화기학 서울대학교 의과대학
  18. 소화성 궤양 김종숙
  19. 實用中西醫結合診斷治療學 陳貴延;楊思樹
  20. 實用中醫脾胃病學 馬貴同(外)
  21. 中國中西醫結合雜誌 v.11 no.5 宏觀辦證和微觀辦證結合的硏究 危北海(外)
  22. 新中醫 v.26 no.10 二黃三七湯治療幽門螺族菌相關性胃炎130例 張立營(外)
  23. 上海中醫雜誌 v.7 胃聖口服液治療治療幽門螺族간菌的療效觀察 泰嵐
  24. 陳修園醫書 72種 v.1 陳修園
  25. 大韓韓醫學雜誌 v.12 no.2 丹參飮과 그 구성약물이 瘀血病態模型 趙南仁
  26. 원광한의학 v.5 no.1 丹參飮이 실험동물의 심혈관계에 미치는 영향 신선호(外)
  27. 동국대학교 한의학 연구소 논문집 v.3 노년 위병을 治療한 경험 方學善
  28. 中醫方劑學 南京中醫學院
  29. Lab. Delo. v.12 Determination of the activity of urease in the gastric muco sa Malov Lu S.
  30. J. Biol. Chem. v.244 The regulation of rat liver xanthine oxidase: Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O) Stirpe, F.;Della Corte, E.
  31. Gastroenterology v.87 Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: Assessment of inflammation in rat and hamster models Krawisz, J.E.;Sharon, P.;Stenson, W.F.
  32. J. Pharm. Pharmacol. v.35 Lysosomal enzyme release and ethanol-induced gastric lesions in rats Chiu, P.J.S.;Nemulapalli, S.;Barnett, A.
  33. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction Ohkawa, H.;Ohishi, N.;Yaki, K.
  34. Arch. Biochem. Biophys. v.82 Tissue sulfhydryl group Ellman, G.L.
  35. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent Lowry, O.H.;Rosebrough, N.J.;Farr, A.L.;Randall, R.J.
  36. 본초학 이상인
  37. 본초학 전국한의과대학 본초학교수(編)
  38. J. Pharm. pharmacol. v.41 Mechanistic toxicology: A radical perspective David, R.
  39. FASEB. J. v.1 Oxidants and human disease: Some new concepts Barry, H.
  40. Pharmacol. Ther. v.37 no.2 Glutathione, free radicals and chemotherapeutic agents: Mechanism of free radical induced toxicity and glutathione dependent protection Ross, D.
  41. J. Biol. Chem. v.245 A mechanism for the production of ethylene from methional: The generation of the hydroxyl radical by xanth ine oxidase Beauchamp, C.;Fridovich, I.
  42. J. Biol. Chem. v.266 Hydrogen peroxide causes th fatal injury in human fibroblasts exposed to oxygen radicals Simon, R.H.;Scoggin, C.M.;Patterson, D.