The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effects of Yukmijihwang-tang, Taeksa-tang, Silbi-um on Mesangial cell Proliferation, Fibronectin Synthesis, MHC-class II Expression

육미지황탕(六味地黃湯),택사탕(澤瀉湯), 실비음(實脾飮)이 메산지움세포 증식, Fibronectin 합성 및 MHC-class II 발현에 미치는 영향(影響)

  • Ahn, Sae-Young (Dept. of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Doo, Ho-Kyung (Dept. of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Jin-Sin (Dept. of Internal Medicine, College of Oriental Medicine, Kyunghee University)
  • 안세영 (경희대학교 한의과대학 신계내과학교실) ;
  • 두호경 (경희대학교 한의과대학 신계내과학교실) ;
  • 이진신 (경희대학교 한의과대학 신계내과학교실)
  • Published : 2000.11.30
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Abstract

Objective : To analyze the effects of Yukmijihwang-tang, Taeksa-tang, Silbi-um on mesangial cell proliferation, fibronectin synthesis and MHC-class II expression. Methods : Laboratory studies were performed with the method of surface enzyme immunoassays or flow cytometry after addition of peripheral blood mononuclear cells(PBMC) supernatants treated with medications using the cultured human mesangial cells. Results : 1. Silbi-um produces more suppressive effect than control group and hydrocortisone group on the mesangial cell proliferation. In Yukmijihwang-tang, Taeksa-tang and Silbi-um, mesangial cell proliferation significantly decreased than in hydrocortisone group 2. In the 'without fetal bovine serum' study, Yukmijihwang-tang take more suppressive effect than Control group on the fibronectin synthesis. In the 'with fetal bovine serum' study, Yukmijihwang-tang, Taeksa-tang, Silbi-um all have suppressive effect, but it hasn' t any statistical significance. 3. Yukmijihwang-tang, Taeksa-tang, Silbi-um all have a suppressive effect on the MHC-class II expression. Conclusions : Herb medicine generally show a suppressive effect on the suppression of the mesangial cell proliferation, fibronectin synthesis and MHC-class II expression.

Keywords

References

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