The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Cordyceps militalis on the penile nitric oxide synthase activity and the level of blood testosterone in hydrocortisone acetate-treated rats

동충하초(冬蟲夏草)가 Hydrocortisone을 투여한 흰쥐의 Nitric Oxide Synthase 활성 및 Testosterone 함량에 미치는 영향

  • Min, Gun-Woo (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Park, Jong-Hyuck (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Yoon, Cheol-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Shin, Uk-Seob (Dept. of Pharmacy, Dongguk Medical Center) ;
  • Han, Yeong-Hwan (Dept. of Biology, College of Natural Science, Dongguk Univ.) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.)
  • 민건우 (동국대학교 한의과대학 내과학 교실) ;
  • 박종혁 (동국대학교 한의과대학 내과학 교실) ;
  • 윤철호 (동국대학교 한의과대학 내과학 교실) ;
  • 신억섭 (동국대학교 의료원 약제과) ;
  • 한영환 (동국대학교 자연과학대학 생물학과) ;
  • 정지천 (동국대학교 한의과대학 내과학 교실)
  • Published : 2000.11.30
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Abstract

The fallowing are the results of the experimental studies of Cordyceps militaris (CM) on the penile nitric oxide synthase (NOS) activity and the level of blood testosterone in hydrocortisone acetate-treated rats. CM was tested for the effects on activity of xanthine oxidase and lipid peroxidation in penis of hydrocortisone acetate-treated rats. In vitro, CM didn't effect the levels of lipid peroxide and the activity of NOS. In the penis of hydrocortisone acetate-treated rats, lipid peroxide, the activities and ratio of type conversion of xanthine oxidase were increased but activity of NOS and content of nitrite were decreased. In vivo, after administration of CM to hydrocortisone acetate-treated rats, levels of lipid peroxide in penis was decreased. Also, the activities and ratio of type conversion of xanthine oxidase were decreased, too. The body weight and concentration of testosterone in the blood were increased. The effects of Cordyceps militalis Broth did better than the effects of Cordyceps militalls Mycelia, These results suggest that CM decrease the activities of free radical generating enzymes such as xanthine oxidase which form lipid peroxide and increase the penile NOS activity and the level of blood testosterone in hydrocortisone acetate-treated rats. Conclusively, CM is capable of improving of sexual ability in hydrocortisone acetate-treated rats.

Keywords

References

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