기관지(氣管支) 평활근(平滑筋)에 미치는 백부근(百部根)의 효과(效果)

Effects of Radix Stemonae on the Airway Smooth Muscle

  • 김성규 (원광대학교 한의과대학 약리학교실) ;
  • 우원홍 (원광대학교 한의과대학 해부학교실) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실) ;
  • 한종현 (원광대학교 한의과대학 약리학교실)
  • Kim Sung-Kyu (Dept. of Pharmacology, College of Oriental Medicine, Wonkwang University) ;
  • Woo Won-Hong (Dept. of Anatomy, College of Oriental Medicine, Wonkwang University) ;
  • Ryu Do-Gon (Dept. of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Han Jong-Hyun (Dept. of Pharmacology, College of Oriental Medicine, Wonkwang University)
  • 발행 : 2000.03.27

초록

The purpose of the present study is to determine the effect of Radix Stemonae on histamine induced tracheal smooth muscle contraction in guinea pigs. Guinea pig(500g, male) were killed by $CO_2$ exposure and a segment (8-10mm) of the thoracic trachea from guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine (His) which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for histamine ($10^{-7}∼10^{-4}M$). Contractions evoked by His ($ED_{50}$) were inhibited significantly by Radix Stemonae. In guinea pig tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was 87.4% (p<0.01) after $100{\mu}l/ml$ Radix Stemonae. Following treatment with propranolol, the mean percent inhibition caused by $100{\mu}l/ml$ Radix Stemonae fell to 16.2% in guinea pig induced by histamine contraction. Indomethacin and methylene blue($10^{-7}M$) did not significantly alter the inhibitory effect of Radix Stemonae. These results indicate that Radix Stemonae can relax histamine induced contraction of guinea pig tracheal smooth muscle, and that this inhibition involves sympathetic effects.

키워드

참고문헌

  1. 原色臨床本草學 辛民敎
  2. 和漢藥物學 古木敬次郞
  3. 중약대사전 강소신의학원(편)
  4. Physiol. Pflugers Arch, ges.
  5. Br. J. Pharmac. v.91 The obligatory role of calcium in the development of antigen-induced airway hyperreactivity to cold provocation in the rat isolated trachea N. Chand;W. Diamantis;R. D. Sofia
  6. Statistical Methods Snedecor, G. H.;W. G. Cochran
  7. 黃帝內經素問譯解 楊維傑
  8. 黃帝內經靈譯樞解 楊維傑
  9. 醫學入門 이천
  10. 東醫肺系內科學 李珩九
  11. 東醫寶鑑 許浚
  12. 實用中醫內科學 上海科學技術出版社
  13. 中醫內科學 張伯臾
  14. 臟腑內科學 崔鍾百
  15. 호흡기학 서울대학교 의과대학
  16. 동의학사전 과학백과사전종합출판사
  17. 동의내과증상의 감별과 치료 민순실
  18. 健康診斷法 Babara, Bates
  19. 內科學 v.Ⅱ 李文鎬(外)
  20. 最新診斷과 治療 金東輝(外)
  21. Am. Rev. Respir. Dis. v.118 Bronchial hyperirritability in healthy subjects after exposure to ozone Golden, J. A.;Nadel J. A.;Boushey H. A.
  22. Am. Rev. Respir. Dis. v.127 Importance of airway inflammation for hyperresponsiveness induced by ozone Holtzan M. J.;Fabbri L. M.;O Byrne P. M.;Gold B. D.;Aizawa H.;Walters E. H.;Alpert S. E.;Nadel J. A.
  23. J. Appl. physiol. v.58 Respiratory epithelium inhibits bronchial smooth muscle tone Flavahan N. A.;L. L. Aarhuus;T. J. Rimele;P. M. Vanhoutte
  24. 半瓜丸이 guinea pig의 氣管支 平滑筋에 미치는 影響 盧丞錫
  25. 淸金湯의 效能에 關한 實驗的 硏究 金應植
  26. Am. Rev. Respir. Dis. v.130 Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure O'Byrne, P. M.;Walters E. H.;Gold B. D.;Aizawa H. A.;Fabbri L. M.;Alpert S. E.;Nadel J. A.;Holtzman M. J.
  27. Am. Rev, Respir. Dis. v.130 Indomethacin inhibits the airway hyperresponsiveness but not the neurtrophil influx induce by ozone in dogs O'Byrne, P. M.;Walters E. H.;Aizawa H. A.;Fabbri L. M.;Holtzman M. J.;Nadel J. A.