Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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The effect of Rhemanniae radix extract on allergic contact dermatitis on Mice induced by DNCB

생지황(生地黃) 추출물(抽出物)이 DNCB로 유발(誘發)된 생쥐의 Allergy성(性) 접촉피부염(接觸皮膚炎)에 미치는 영향(影響)

  • 신광식 (동국대학교 한의과대학 내과학교실) ;
  • 손정숙 (동국대학교 한의과대학 내과학교실) ;
  • 김동은 (동국대학교 한의과대학 내과학교실) ;
  • 전원준 (동국대학교 한의과대학 내과학교실) ;
  • 정승현 (동국대학교 한의과대학 내과학교실) ;
  • 신길조 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실)
  • Published : 2000.12.05
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Abstract

Allergic contact dermatitis is a common skin disease resulting from specific immunologic to topically applied various allergen. After Dinitrochlorobenzene (DNCB) secondary sensitization, the ICR mice administered Rhemanniae radix extract (RRE) was observed to ascerstain the effect of RRE on allergic contact dermatitis. Purpose of this study was to investigate contact hypersensitivity assay, abdominal skin morphologic changes. Including mast cells and cell-surface glycoconjugates. The change of interleukin 2 (IL-2) receptor (CD25R). ICAM in abdominal skin, lymph node of inguinal region, and electro microscope-morphologic changes of abdominal skin. The results of this study were as follows: 1. The contact hypersensitivity assay, the ear swelling in the RRE had lesser probability than in the ACD Group. 2. In the general morphologic change of skin, hyperplasia of keratinocytes, distribution of vasculogenesis and epidermal lymphocytes infiltration were decreased in the RRE group compared with the ACD group. In epidermal basal layer and prickle layer, cell damage was decreased in the RRE group compared with the group painted with ACD. 3. MasT-cell in dermis was decreased in the RRE group compared with the group painted with DNCB. 4. Distribution of interlukin-2 Receptior positive cell and ICAM positive cell in dermis was decreased in the RRE Group compared with the ACD group. 5. Distribution of helper T-lymphocyte and cytotoxic T-lymphocite in inguinal nodes was decreased in the RRE group, and was observed well in paracortical area and cortical cord. 6. Distribution of apoptotic cell was appeared in the RRE group compared with the ACD group, in skin, dermis. in inguinal nodes, paracortical area observed well. With above results, the restarint of immunosuppression occuring in Allergic contact dermatitis is resulted in the slow progress the effect of Allergic contact dermatitis, and it is thought that ithis fact has a series of relation with apoptosis.

Keywords

References

  1. 알레르기의 진료 이기영
  2. 대한피부과학회지 v.30 no.2 강원도 지역 피부질환의 통계적 고찰(1985-1989) 원진형;허원;안성구;이승헌
  3. 대한피부과학회지 v.24 no.3 접촉피부염의 역학적 연구 은희철;고창조;국홍일(외)
  4. 피부과학 대한피부과학회
  5. 면역학 서울대학교 의과대학
  6. 알레르기와 韓方 정규만(편저)
  7. 實用中醫外科學 顧伯華(主編)
  8. 中醫外科學 傳景華(主編)
  9. 中醫外科學 顧伯康(主編)
  10. 大韓韓醫學會誌 v.11 no.2 免疫疾患의 韓方槪念과 治療에 關한 文獻的 考察 蔡禹錫
  11. 大韓外官科學會誌 v.4 no.1 消風散과 加味消風散이 免疫反應 및 抗알레르기에 미치는 影響 김중호;채병윤
  12. 大韓外官科學會誌 v.4 no.1 當歸飮子 水抽出液이 抗 ALLERGY반응과 MOUSE의 免疫細胞機能에 미치는 影響 노석선;이기남
  13. 大韓外官科學會誌 v.6 no.1 消風除痒湯이 抗알레르기, 鎭痛$\cdot$消炎效果에 미치는 影響 김수정;김중호;채병윤
  14. 大韓外官科學會誌 v.6 no.1 銀花甘草湯과 加味方이 抗알레르기, 解熱, 消炎, 鎭痛效果에 미치는 影響 최규동;김중호;채병윤
  15. 大韓外官科學會誌 v.6 no.1 加味淸心蓮子飮 煎湯液이 抗ALLERGY반응과 MOUSE의 免疫細胞機能에 미치는 影響 이연숙;노석선
  16. 大韓外官科學會誌 v.8 no.1 升麻葛根湯加味方이 마우스의 抗ALLERGY 및 免疫反應에 미치는 影響 김남권;황충연;임규양
  17. 加味升葛湯이 DNCB로 誘導된 생쥐의 Allergy성 接觸皮膚炎에 미치는 影響 이준희
  18. 連翹敗毒散加味方이 DNCB로 誘導된 생쥐의 Allergy성 接觸皮膚炎에 미치는 影響 권오성
  19. 도설 한방의약대사전 진존인
  20. 中藥學 顔正華(主編)
  21. 신씨본초학<각론> 신길구
  22. 和漢藥の世界 木村雄四郞
  23. 中藥學 周鳳梧
  24. 中草藥學 上海中醫學院
  25. 神農本草經 吳普
  26. 대한해부학회지 v.27 no.4 Cyclosporin A가 생쥐 비장에 미치는 영향에 관한 면역조직화학적 연구 김진택;김동환;안상현
  27. 동국논집 v.14 Sarcoma 180 cell이 생쥐 가슴샘의 T 림프구와 IL-2수용기의 변화에 미치는 면역조직화학적인 연구 김진택;김동환;안상현
  28. 대한의학협회지 v.27 약물에 의한 접촉피부염 김덕현
  29. 대한의학협회지 v.27 접촉피부염의 기전과 첩포시험의 적용 임수덕
  30. 諸病原候論 巢元方
  31. 外科正宗 陳實功
  32. 大韓外官科學會誌 v.10 no.1 接觸性皮膚炎에 關한 文獻的 考察 전재홍;김현아;강윤호
  33. 大韓外官科學會誌 v.7 no.1 回春凉膈散이 抗알레르기 및 消炎, 鎭痛, 解熱效果에 미치는 影響 김경준;김중호;채병윤
  34. 중의잡지 양음활혈등복방대동물항체형성 영향적 연구 소상부
  35. 生地黃, 乾地黃, 熟地黃이 세포성면역반응 및 체액성면역반응에 미치는 영향 황영명
  36. 中西醫結合雜誌 v.9 no.11 黃芩藥理硏究進展 李忠;郭湘云
  37. Arch. Dermatol. Res. v.286 Topical FK506: suppression of allergic and irritant contract dermatitis in the guinea pig A.I. Lauerma;B.D. Stein;B. Homey;C.H. Lee;E. Bloom;H.I. Maibach
  38. Int. Arch. Allergy Appl. Immunol. v.89 Dendritic Cell Accumulation in Draining Lymph Nodes during the Induction Phaes of Contact Allergy in Mice A. Kinnaird;S.W. Peters;J.R. Foster;I. Kimber
  39. Allergy v.51 Modulation of intercelluar adhesion molecuiel(ICAM-1) expression on the human mast-cell line(HMC)-1 by inflammatory mediators B. Wedi;J. Elsner;W. Czech;J.H. Butterfield;A. Kapp
  40. British Jounal of Dermatology v.128 Large increase of Langerhans cells in human skin lymph derived from irritant contact dermatitis C.U. Brand;T.Hunziker;A. Limat;L.R. Braathen
  41. American Journal of Contact Dermatitis v.4 no.4 Cytokines in Contact Dermatitis Daniel N.Sauler;Saveria Pastore
  42. Int. Arch. Allergy Appl. Immunol. v.90 Assessment of the F-unctional Activity of Antigen-Bearing Dendritic Cells Isolated from the Lymph Nodes of Contact-Sensitized Mice David A. Jones;Alan G. Morris;Ian Kimber
  43. J. Immunol. methods v.169 An invitro test for endocytotic activation of murine epidermal Langerhans cells under the influence of allergens Detlef Becker;Gerhard Kolde;Konrad Reske;Juren Knop
  44. J. Invest. Dermatol. v.99 Increased Level of Intracellar MHC Call II Molecules in Murine L-angerhans Cells Following In Vivo and In Vitro Administration of Contact Allergens Detlef Becker;Mansour Mohamadzadeh;Konrad Reske;Jurgen Knop
  45. J. Invest. Dermatol. v.98 Contact Allergens Modulate the Expression of MHC Class II Molecules on Murine Epidermal Langerhans Cells by Endocytotic Mechanisms Detlef Becker;Ursula Neib;Sabine Neis;Konrad Reske;Jurgen Knop
  46. J. Invest. Dermatol. v.96 Increased Number of Dendritic Cells in Draining Lymph Nodes Accompanies the Generation of Contact Photosensitivity G.Frank Gerberick;Cindy A. Ryan;E. Robert Fletcher;Angela D. Foward;Michael K. Robinson
  47. Korea J. Deramat. v.23 no.2 Cyclosporin modulates DNCB contact hypersensitivity reaction in guinea pigs Ik Jo;Won Houh
  48. Glucocorticoids Encyclo. Immunol. J. John Cohen
  49. British. Foun. Dermato. v.122 The influence of area of application on sensitization by dinitrochlorobenzene J.L. Rees;P.S. Friedmann;J.N.S. Mattews
  50. Contact Dermatitis v.26 Role of keratinocytes in allergic contact dermatitis Jonathan N.W.N. Barker
  51. J. Immunol. v.127 Epidermal cell derived thymocyte activating factor Luger, T.A.;Stadler, B.M.
  52. Int. Arch. Allergy Immunol. v.101 Immediate and Delayed(Late phase) Dermal Contact Sensitivity Reactions in Guinea Pigs Passive Transfer by lgG1 Antibodies, Initiation by Mast-cell Deranulation, and Supperssion by Soybean Proteinase Inhibitor K. Gregory Moore;Arthur M. Dannenberg Jr.
  53. Am. J. Contact Dermatitis v.4 no.1 The Murine Local Lymph Node Assay : Principles and Practice lan Kimber
  54. Immunology v.71 Phenotypic characteristics of antigen-bearing cells in the drainning lymph nodes of contact sensitizen mice M. Cumberbatch;I. Kimber
  55. Ann. Rev. Immunol. v.11 The IL-2 receptor complex : Its structure, function and target genes inami, Y.;Kono, T.;Miyazaki, T.;Taniguchi, T.
  56. Immunology v.78 Sensitzation of mice to chemical allergens modulates the responsiveness of isolated mast-cells to IgE-dependent activation M.R. Holliday;R.J. Dearman;I. Kimber;J.W. Coleman
  57. J. Immunology v.145 no.9 Evidence that cutaneous antigen-present-ing cells migrate to regional lymph nodes during contact sensitization Margaret L. Kripke;C. Gwyneth Munn;Amminikutty Jeevan;Jun Min Tang;Corazon Bucana
  58. Am. J. Contact Dermatitis v.5 no.2 Role of Macrophages and Dendritic Cells in Contact Dermatitis Monte S. Meltzer
  59. Department of Dermatology v.30 no.3 Immune Regulation in Allergic and Irritant Skin Reactions Ole Baadsgaard;Timothy Wang B.S.
  60. Clin. Exp. Immunol. v.91 Early time course of recruitment of immune surveillance in human skin after chemical provocation P.S. Friedmann;I. Strickland;A.A. Memon;P.M. Johnson
  61. Am. J. Contact Dermatitis v.2 no.3 Humoral and Cellular Immunity in Different Phase of Contract Dermatitis P. Torres;F. Guerra;A. Aenas;R. Miguel;C.Moreno;J.C. Daza;M. Santamaria;P. Sanchez Guijo
  62. Contact Dermatitis v.22 Erythema multiforme due to DNCB R. Viraben;J.L. Labrousse;J. Bazex
  63. Arch. Dematol. v.127 Recent Developments in th Pathogenesis of Allergic Contact Dermatitis Richard S. Kalish
  64. J. Invest. Dermatol. v.79 Epidermal cell production of thymocyte activating factor Sauder, D.N.;Carter, C.S.;Kats, S.I.
  65. Immunology v.71 Systemic migration of dendritic cells during contact sensitization S. Hill;A.J. Edwards;I. Kimber;S.C. Knight
  66. Science v.240 Interleukin-2;inception, impact and implications Smith, K.L.
  67. J. Exp. Med. v.166 Localization of antigen of lymph node dendritic cells after xposure to the contact sensitizer fluorescein isothic-yanate functional and morphological studies Steven E. macatonia;Stella C. Knight;Andrew J. Edwards;Stephen Griffitos;Patricia Fryer
  68. Arch. Dermatol. Res. v.282 Histamine metabolism in delated type hypersensitivity-Comparative analysis with cellular infiltrates T. Tachibana;K.I. Toda;F.Furukawa;S.Taniguchi;S.Imamura
  69. Eur. J. Immunol. v.25 Oral tolerance to haptens: intestinal epithelial cells from 2.4-d-inintrochloro benzenr-fed mice inhibit hepten-specific T-cell activation in vitro Veronique Galliaerde;Cyril Desvignes;Eric Peyron;Dominique Kais-erlian
  70. Immunology v.72 Enhancement of a delayed hypersensitivity reaction to a contact allergen, by the systemic administration of interleukin-2 Y. Zaloom;L.P. Walsh;P.McCulloch;G. Gallagher