Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지

THE USE OF VANCOMYCIN-IMPREGNATED POLYMETHYLMETACTYLATE BEADS FOR THE TREATMENT OF CHRONIC OSTEOMYELITIS

반코마이신을 함유한 Polymethylmetacrylate 비드를 이용한 만성 골수염의 치험례

  • Lee, Hyung-Seok (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Park, Young-Ju (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Choi, Dong-Ju (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Kim, Mi-Ja (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Jang, Gae-Pyo (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Kim, Jung-Rae (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Kim, Sun-Youp (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Ahn, Byung-Keun (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Hallym University)
  • 이형석 (한림대학교 의과대학 치과학교실 구강악안면외과) ;
  • 박영주 (한림대학교 의과대학 치과학교실 구강악안면외과) ;
  • 최동주 (한림대학교 의과대학 치과학교실 구강악안면외과) ;
  • 김미자 (한림대학교 의과대학 치과학교실 구강악안면외과) ;
  • 장계표 (한림대학교 의과대학 치과학교실 구강악안면외과) ;
  • 김정래 (한림대학교 의과대학 치과학교실 구강악안면외과) ;
  • 김선엽 (한림대학교 의과대학 치과학교실 구강악안면외과) ;
  • 안병근 (한림대학교 의과대학 치과학교실 구강악안면외과)
  • Published : 2000.12.31
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Abstract

One of the current treatment methods for chronic osteomyelitis is removal of the infected and necrotic tissue to reduce the bacterial concentration as much as possible. This is performed concomitantly with antibiotic therapy. Chronic osteomyelitis(C.O.) implies chronic ischemia of the diseased bone. Thus, the treatment for C.O. requires high systemic level of antibiotics. In some cases, however, inherent undesirable adverse effects(for example, nephrotoxicity, ototoxicity, and others) may render this course of treatment difficult. Knowing that residual monomers are released from hardened bone cement, installation of antibiotic-impregnated PMMA(polymethyl-methacrylate) beads in situ have been one of treatment methods of C.O. When introduced into the wound, they established an exceedingly high level of local antibiotics for prolonged period without high systemic level of antibiotics. We experienced favorable results with vancomycin-impregnated PMMA beads for the treatment of C.O. of the mandible. So, we report it with literature reviews.

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