Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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DEVELOPMENT OF MOLDABLE BONE REGENERATING THERAPEUTICS USING PARTIALLY PURIFIED PORCINE BONE MORPHOGENETIC PROTEIN AND BIORESORBABLE POLYMER

Poly(L-lactide)와 돼지골기질에서 추출 부분정제한 골형성단백을 이용한 조형가능성 골형성유도체의 개발

  • Lee, Jong-Ho (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Chung, Chong-Pyung (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
  • Lee, Sung-Jin (Dept. of Industrial Pharmacy, College of Pharmacy, Ehwa Woman's Unversity)
  • 이종호 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 정종평 (서울대학교 치과대학 치주과) ;
  • 이승진 (이화여자대학교 약학대학)
  • Published : 2000.04.30
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Abstract

The purpose of this study was to develop an osteogenic, biodegradable material using polymer and BMP. It was designed to have structural function and be moldable, for the reconstruction of load bearing areas and deformities of various configurations. Bone apatite was added to Poly(L-lactide)(PLLA) and made porous for osteoconductability and ease of BMP loading. The materials, with or without BMP purified from porcine bone matrix, were evaluated in cranial bone defect models in rats for biocompatibility and bone regeneration capability. The following results were obtained: The PLLA-BMP material with BMP added to the polymer showed 30% healing of cranial bone defects in rats during the 2 weeks to 3 months period of observation. The moldable PLLA agent without BMP also showed 25% bone healing capacity. Although new bone formation was incomplete in the critical size defect of rat cranium, it can be concluded that the unique moldability of those agents makes them useful for the reconstruction of various bone defects and maxillofacial deformities.

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