Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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A comparative study on the inhibitory effects of mast cell-mediated allergic reactions by artificially cultured and wild Acanthopanax senticosus

  • Yi, Jin-Mu (Department of Oriental Pharmacy, College of Pharmacy, and Center of Oriental Medicinal Science, Wonkwang University) ;
  • Jeong, Hyun-Ja (Department of Oriental Pharmacy, College of Pharmacy, and Center of Oriental Medicinal Science, Wonkwang University) ;
  • Shim, Kyung-Shik (Department of Oriental Pharmacy, College of Pharmacy, and Center of Oriental Medicinal Science, Wonkwang University) ;
  • Lee, Kang-Yong (Department of Oriental Pharmacy, College of Pharmacy, and Center of Oriental Medicinal Science, Wonkwang University) ;
  • Kim, Jeong-Sook (Department of Oriental Pharmacy, College of Pharmacy, and Center of Oriental Medicinal Science, Wonkwang University) ;
  • Zheng, Cui (Shenyang pharmacenfical University) ;
  • Tomoko, Jippo (Department of Pathology, Osaka University Medical school) ;
  • Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy, and Center of Oriental Medicinal Science, Wonkwang University)
  • Published : 2000.08.30
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Abstract

We compared the effect between CAS and WAS(root, stem) on mast cell-mediated allergic reaction. CAS, WAS-root and WAS-stem, significantly inhibited compound 48/80-induced systemic allergic reaction(1g/kg) and histamine release from RPMC(1mg/ml). CAS, WAS-root and WAS-stem also inhibited passive cutaneous anaphylactic reaction. In addition, IgE-induced $TNF-{\alpha}$ secretion from RBL-2H3 was inhibited by pretreatment of CAS, WAS-root or WAS-stem$(0.01{\mu}g/ml)$. Taken together, inhibitory effect on mast cell-mediated allergic reactions of WAS-root is greater than those of WAS-stem but less than those of CAS.

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