Journal of Pharmaceutical Investigation
- 제30권4호
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- Pages.241-246
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- 2000
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
케토롤락트로메타민 서방성 펠렛의 약물속도론적 평가
Pharmacokinetic Evaluation of Ketorolac Tromethamine Sustained-Release Pellets after Oral Administration in Rabbits
- 곽손혁 (충남대학교 약학대학) ;
- 황성주 (충남대학교 약학대학) ;
- 장혁 (충남대학교 약학대학) ;
- 남경완 (충남대학교 약학대학) ;
- 문영걸 (충남대학교 약학대학) ;
- 이해방 (한국화학연구소 화학소재연구부 2팀) ;
- 조선행 (한국화학연구소 화학소재연구부 2팀) ;
- 육순홍 (한남대학교 분자학과) ;
- 이한구 (대화제약(주) 중앙연구소) ;
- 정상영 (대화제약(주) 중앙연구소) ;
- 이영원 (충남대학교 수의과대학)
- Kwak, Son-Hyok (College of Pharmacy, Chungnam National University) ;
- Hwang, Sung-Joo (College of Pharmacy, Chungnam National University) ;
- Jiang, Ge (College of Pharmacy, Chungnam National University) ;
- Nam, Kyung-Wan (College of Pharmacy, Chungnam National University) ;
- Moon, Young-Girl (College of Pharmacy, Chungnam National University) ;
- Lee, Hai-Bang (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
- Cho, Sun-Hang (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
- Yuk, Soon-Hong (Department of Macromolecular Science, Hannam University) ;
- Lee, Han-Koo (Central Research Institute, Dae Hwa Pharm. Co., Ltd.) ;
- Jeong, Sang-Young (Central Research Institute, Dae Hwa Pharm. Co., Ltd.) ;
- Lee, Young-Won (College of Veterinary Medicine, Chungnam National University)
- 발행 : 2000.12.20
초록
To develop a sustained-release preparation containing ketorolac tromethamine, two sustained-release pellet formulations were evaluated with a pharmacokinetic study as compared with a conventional commercial tablets (10 mg