Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Statistical Consideration on the Similarity in Dissolution Profile of Two Fast Releasing Tablets

속용성 정제간의 용출유사성에 대한 통계학적 고찰

  • Cho, Jung-Hwan (College of Pharmacy, Sookmyung Women's University) ;
  • Lee, Se-Hee (College of Pharmacy, Sookmyung Women's University) ;
  • Kim, Hee-Sun (College of Pharmacy, Sookmyung Women's University) ;
  • Oh, Seaung-Youl (College of Pharmacy, Sookmyung Women's University)
  • 조정환 (숙명여자대학교 약학대학) ;
  • 이세희 (숙명여자대학교 약학대학) ;
  • 김희선 (숙명여자대학교 약학대학) ;
  • 오승열 (숙명여자대학교 약학대학)
  • Published : 2000.06.20
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Abstract

We have studied the dissolution kinetics of two fast releasing tablets in four media, and the similarity of dissolution profiles was compared using 3 methods. Two of the methods were introduced from statistical algorithm of distance methods, which are maximum distance and Mahalanobis distance. The dissolution kinetics were also analysed using FDA method for similarity evaluation, and the results were compared with those obtained using the distance methods.

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