한국한의학연구원논문집 (Korean Journal of Oriental Medicine)
- 제6권1호
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- Pages.123-132
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- 2000
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- 1229-3377(pISSN)
육미지황환(六味地黃丸) 에탄올 추출물이 난소제거 흰쥐의 경골 소주골에 미치는 영향
Effect of Ethanol Extract of Yukmijiwhang-Whan on Trabecular Bone Area in OVX Rats
- 김정숙 (한국한의학연구원 한약제제연구부) ;
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하혜경
(한국한의학연구원 한약제제연구부) ;
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이제현
(경희대학교 약학대학 한약학과) ;
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송계용
(중앙대학교 의과대학 병리학교실) ;
- 김혜진 (한국한의학연구원 한약제제연구부) ;
- 신선미 (한국한의학연구원 한약제제연구부)
- Kim, Chung-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
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Ha, Hye-Kyung
(Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
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Lee, Je-Hyun
(Department of Oriental Pharmaceutical Science, College of Pharmacy, KyungHee University) ;
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Song, Kye-Yong
(College of Medicine, Chung-Ang University) ;
- Kim, Hye-Jin (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
- Shin, Sun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
- 발행 : 2000.04.30
초록
Bone is continuously remodeled during adult life with the resorption of old bone by osteoclasts and its subsequent replacement by osteoblast. Bone homeostasis is maintained by a balance between activities of osteoblasts and osteoclasts, but an imbalance between resorption and formation results in bone diseases including osteoporosis. Osteoblasts line up on the bone surface, especially regions of new bone formation, lay down bone matrix (osteoid) in orderly lamellae and induce its mineralization. Thus, the increased activity of osteoblasts is helpful to treat and prevent osteoporosis. In this study, we examined whether 80% EtOH extract of yukmijiwhang-whan is capable of affecting osteoblast proliferation using human osteoblast-like cell line, MG-63 and Saos-2. In an in vivo experiment, extract of yukmijiwhang-whan was administered for 9 weeks to ovariectomized (OVX) rats. At necropsy, uterus weights were measured, and trabecular bone areas (TBAS) of tibia and the sixth lumbar vertebra were measured by bone histomorphology. The maximum cell proliferation of MG-63 caused by extract of yukmijiwhang-whan at