Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Screening on Radical Scavenging Activity of Marine Microalgae

해양미세조류의 라디칼소거활성 검색

  • Choi, Jin-Seok (Department of Chemistry, Pukyong National University, Department of Food Science and Technology, Kyungsung University) ;
  • Lee, Won-Kap (Department of Chemistry, Pukyong National University, Department of Food Science and Technology, Kyungsung University) ;
  • Kim, Dong-Soo (Department of Food Science and Technology, Kyungsung University) ;
  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Choi, Jae-Sue (Department of Food and Life Science, Pukyong National University) ;
  • Jung, Jee H. (College of Pharmacy, Pusan National University) ;
  • Im, Kwang-Sik (College of Pharmacy, Pusan National University) ;
  • Choi, Won-Chul (Division of Biological Sciences, Pusan National University) ;
  • Son, Byeng-Wha (Department of Chemistry, Pukyong National University, Department of Food Science and Technology)
  • 최진석 (부경대학교 화학과, 경성대학교 식품공학과) ;
  • 이원갑 (부경대학교 화학과, 경성대학교 식품공학과) ;
  • 김동수 (경성대학교 식품공학과) ;
  • 최홍대 (동의대학교 화학과) ;
  • 최재수 (부경대학교 식품생명과학과) ;
  • 정지형 (부산대학교 약학대학) ;
  • 임광식 (부산대학교 약학대학) ;
  • 최원철 (부산대학교 생물학과) ;
  • 손병화 (부경대학교 화학과)
  • Published : 2000.06.30
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Abstract

In order to screen new radical scavenging principle which is expected to be antiaging drug lead, we have investigated 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the marine microalgae, greenalgae(10 speices), diatom (10 speices) and blue-green algae (10 speices). The significant activities$(IC_{50}:\;<100\;{mu}g/ml)$ were observed in 4 species of green algae (MA002, 006, 009, 010), 1 species of diatom (MA015) and 5 species of blue-green algae (MA017, 018, 019, 024, 025). Within the scope of family tested, MA009 $(IC_{50}:\;=78\;{mu}g/ml)$, MA015 $(IC_{50}:\;=38\;{mu}g/ml)$ and MA019 $(IC_{50}:\;=41\;{mu}g/ml)$ displayed the most significant activity. Among the marine microalgae tested at family level, cyanophycean blue-green algae was shown to be the most active family on screening of new bioactive compounds.

Keywords