Isolation of COX-2 Inhibitors from Alpinia officinarum

양강으로부터 COX-2 억제활성물질의 분리

  • Kim, Ju-Sun (Natural Products Research Institute, Seoul National University) ;
  • Son, Kun-Ho (Department of Food and Nutrition, Andong National University) ;
  • Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) ;
  • Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • 김주선 (서울대학교 천연물과학연구소) ;
  • 손건호 (안동대학교 식품영양학과) ;
  • 김현표 (강원대학교 약학대학) ;
  • 장현욱 (영남대학교 약학대학) ;
  • 강삼식 (서울대학교 천연물과학연구소)
  • Published : 2000.03.30

Abstract

By bioassay-guided fractionation followed by chromatographic separation of the MeOH extract of Alpinia Rhizome, five COX-2 inhibitors were isolated and characterized as pinocembrin, galangin 3-methyl ether, galangin, kaempferid, and 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone.

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