Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Tilliacorine on Haematological and Biochemical Parameters

  • Khasnobis, Arnab (Central Drugs Laboratory) ;
  • Seal, Tapan (Botanical Survey of India, Indian Botanic Garden) ;
  • Roychowdhuri, A. (Regional Occupational Health Centre) ;
  • Vedasiromoni, J. Rajan (Indian Institute of Chemical Biology) ;
  • Gupta, Malaya (Department of Pharmaceutical Technology, Jadavpur University) ;
  • Mitra, S.K. (S. N. Pradhan Centre for Neurosciences, University College of Medicine) ;
  • Mukherjee, Biswapati (S. N. Pradhan Centre for Neurosciences, University College of Medicine)
  • Published : 2000.09.01
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Abstract

Tiliacora racemosa Colebr. belonging to the family Menispermaceae, is the biggest storehouse of diphenyl bisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the root of T. racemosa by the application of modern separation techniques yielded a DBBI alkaloid which was identified as tiliacorine using sophisticated spectroscopic methods (UV, IR, $^1H-NMR$, MS). Haematological study with tiliacorine proved that there was no abnormal haematological results in comparison with the normal values. Chronic toxicity study with tiliacorine revealed that the alkaloid is devoid of any hepatotoxic and nephrotoxic action.

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