The Korean Journal of Physiology and Pharmacology
- Volume 4 Issue 2
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- Pages.121-127
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- 2000
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
The Role of Lipid Peroxidation and Glutathione on the Glycochenodeoxycholic Acid-Induced Cell Death in Primary Cultured Rat Hepatocytes
- Chu, Sang-Hui (Department of Pharmacology, College of Medicine, Ewha Womans University) ;
- Park, Wol-Mi (Department of Pharmacology, College of Medicine, Ewha Womans University) ;
- Lee, Kyung-Eun (Department of Pharmacology, College of Medicine, Ewha Womans University) ;
- Pae, Young-Sook (Department of Pharmacology, College of Medicine, Ewha Womans University)
- Published : 2000.04.21
Abstract
Intracellular accumulation of bile acids in the hepatocytes during cholestasis is thought to be pathogenic in cholestatic liver diseases. The objective of this study was to determine the role of lipid peroxidation and glutathione on the bile acid-induced hepatic cell death mechanism in primary cultured rat hepatocytes. To induce hepatic cell death, we incubated primary cultured rat hepatocytes with glycochenodeoxycholic acid